The Library
Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants
Tools
Baxter, Laura, Jironkin, Aleksey, Hickman, R. D. G., Moore, Jonathan D., Barrington, Christopher, Krusche, Peter, Dyer, Nigel, Buchanan-Wollaston, Vicky, Tiskin, Alexander, Beynon, Jim, Denby, Katherine J. and Ott, Sascha (2012) Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants. The Plant Cell, Vol.24 (No.10). pp. 3949-3965. doi:10.1105/tpc.112.103010 ISSN 1040-4651.
|
Text
WRAP_Ott_Plant Cell-2012-Baxter-3949-65.pdf - Published Version Download (1467Kb) | Preview |
Official URL: http://dx.doi.org/10.1105/tpc.112.103010
Abstract
Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar [Populus trichocarpa], and grape [Vitis vinifera]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QK Botany | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
||||
Library of Congress Subject Headings (LCSH): | Arabidopsis thaliana -- Physiology, Arabidopsis thaliana -- Genetics, Papaya -- Physiology, Papaya -- Genetics, Poplar -- Physiology, Poplar -- Genetics, Thompson seedless grape -- Physiology, Thompson seedless grape -- Genetics, Genetic transcription -- Regulation | ||||
Journal or Publication Title: | The Plant Cell | ||||
Publisher: | American Society of Plant Biologists | ||||
ISSN: | 1040-4651 | ||||
Official Date: | October 2012 | ||||
Dates: |
|
||||
Volume: | Vol.24 | ||||
Number: | No.10 | ||||
Page Range: | pp. 3949-3965 | ||||
DOI: | 10.1105/tpc.112.103010 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), Science Research Investment Fund (SRIF) | ||||
Grant number: | BB/F005806/1 (BBSRC) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year