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High-energy collision-induced dissociation of macromolecules using tandem double-focusing/time-of-flight mass spectrometry
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Bottrill, Andrew R. (2000) High-energy collision-induced dissociation of macromolecules using tandem double-focusing/time-of-flight mass spectrometry. PhD thesis, University of Warwick.
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WRAP_THESIS_Bottrill_2000.pdf - Submitted Version Download (6Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b1369158~S1
Abstract
The first part of this study involves the adaptation of a matrix-assisted laser
desorption/ionisation (MALDI) ion source for a tandem double-focusingltime-offlight
instrument (MAG-TOF). Ion trajectory modelling was carried out for defining
the optimum ion optical configuration for a new extraction region and associated ion
optics that were designed and constructed. Installation of the new ion source resulted
in increased sensitivity and no loss of resolution.
The second part of this study involves the analysis of fullerenes and fullerene
derivatives by high-energy collision-induced dissociation (CID). The structure of
fullerenes formed by coalescence under the conditions of laser desorption were
shown to be that of a single fullerene closed-cage structure. The dissociation of
exohedral fullerene hydride derivatives was investigated.
The third part of this study investigates the high-energy collision-induced
dissociation of polyglycol polymer ions generated by MALDI. Mechanisms have
been proposed for the dissociation of poly(ethylene glycol) and poly(propylene
glycol). High-energy CID has been shown to be particularly useful for the
determination of polymer end-group structure.
| Item Type: | Thesis (PhD) | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Time-of-flight mass spectrometry, Tandem mass spectrometry, Ion sources, Fullerenes -- Analysis | ||||
| Official Date: | September 2000 | ||||
| Dates: |
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| Institution: | University of Warwick | ||||
| Theses Department: | Department of Chemistry | ||||
| Thesis Type: | PhD | ||||
| Publication Status: | Unpublished | ||||
| Supervisor(s)/Advisor: | Derrick, Peter | ||||
| Sponsors: | Unilever (Firm) | ||||
| Extent: | xvi, 199 leaves | ||||
| Language: | eng |
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