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Independent and opposite associations of trunk and leg fat depots with adipokines, inflammatory markers, and metabolic syndrome in middle-aged and older Chinese men and women
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Wu, Hongyu, Qi, Qibin, Yu, Zhijie, Sun, Qi, Wang, Jing, Franco, Oscar H., Sun, Liang, Li, Huaixing, Liu, Yong, Hu, Frank B. and Lin, Xu (2010) Independent and opposite associations of trunk and leg fat depots with adipokines, inflammatory markers, and metabolic syndrome in middle-aged and older Chinese men and women. Journal of Clinical Endocrinology & Metabolism , Vol.95 (No.9). pp. 4389-4398. doi:10.1210/jc.2010-0181 ISSN 0021-972x.
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Official URL: http://dx.doi.org/10.1210/jc.2010-0181
Abstract
Objective: The objective was to investigate associations of regional fat depots with adipokines, inflammatory markers, and risk of metabolic syndrome (MetS) in a Chinese population.
Design and Methods: Trunk and leg fat mass were determined in a population-based sample of 1150 Chinese (479 men and 671 women) aged 50-70 yr by using whole-body dual-energy x-ray absorptiometry scan. Plasma adiponectin, plasminogen activator inhibitor-1 (PAI-1), retinol-binding protein 4 (RBP4), resistin, C-reactive protein, and IL-6 were measured. The updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans was used to define MetS.
Results: Larger body-size adjusted trunk fat mass was significantly associated with lower adiponectin and higher PAI-1, RBP4, C-reactive protein, and IL-6 levels in both genders (P < 0.05). Larger body-size adjusted leg fat mass was significantly associated with higher adiponectin levels in both genders but lower RBP4 and PAI-1 concentrations in men (P < 0.05). Comparing with the lowest body-size adjusted leg fat mass tertile, the odds ratio (95% confidence interval) of MetS in the highest tertile was 0.33 (0.18-0.62; P for trend < 0.001) for men and 0.43 (0.28-0.65; P for trend < 0.001) for women. The association was attenuated with further controlling adipokines and inflammatory markers (P = 0.09 for men and P = 0.004 for women).
Conclusion: In contrast to trunk fat, large leg fat appears to have favorable effects on adipokines, inflammatory markers, and MetS risk among Chinese. The opposite associations between regional fat depots and MetS risk may partially mediated by adipokines and inflammatory status. (J Clin Endocrinol Metab 95: 4389-4398, 2010)
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Journal of Clinical Endocrinology & Metabolism | ||||
| Publisher: | Endocrine Society | ||||
| ISSN: | 0021-972x | ||||
| Official Date: | September 2010 | ||||
| Dates: |
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| Volume: | Vol.95 | ||||
| Number: | No.9 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 4389-4398 | ||||
| DOI: | 10.1210/jc.2010-0181 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Ministry of Science and Technology of China, 863 Program, Shanghai Municipal Science and Technology Commission, International Collaboration Program | ||||
| Grant number: | SIBS2008006, KSCX1-YW-02, 2006CB503900, 2007AA02Z332, 08dj1400601, 2008DFA31960 |
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