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Gamma-butyrolactone and furan signaling systems in streptomyces
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Sidda, John D. and Corre, Christophe (2012) Gamma-butyrolactone and furan signaling systems in streptomyces. Methods in Enzymology, 517 . pp. 71-87. doi:10.1016/B978-0-12-404634-4.00004-8 ISSN 0076-6879.
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Official URL: http://dx.doi.org/10.1016/B978-0-12-404634-4.00004...
Abstract
Streptomyces bacteria produce different classes of diffusible signaling molecules that trigger secondary metabolite production and/or morphological development within the cell population. The biosynthesis of gamma-butyrolactones (GBLs) and 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids (AHFCAs) signaling molecules is related and involves an essential AfsA-like butenolide synthase. This chapter first describes the catalytic role of AfsA-like enzyme then provides details about methods for the discovery and characterization of potentially novel signaling molecules. In section 4, one approach for establishing the biological role of these signaling molecules is presented.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Methods in Enzymology | ||||
Publisher: | Academic Press | ||||
ISSN: | 0076-6879 | ||||
Book Title: | Natural Product Biosynthesis by Microorganisms and Plants, Part C | ||||
Official Date: | October 2012 | ||||
Dates: |
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Volume: | 517 | ||||
Page Range: | pp. 71-87 | ||||
DOI: | 10.1016/B978-0-12-404634-4.00004-8 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Description: | Chapter 4 of "Natural Product Biosynthesis by Microorganisms and Plants, Part C" edited by David A. Hopwood, ISBN: 9780124046344 |
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