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The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron
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Forrest, Michael D., Wall, Mark J., Press, Daniel A. and Feng, Jianfeng (2012) The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. PLoS ONE, Vol.7 (No.12). e51169. doi:10.1371/journal.pone.0051169 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0051169
Abstract
In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na+/K+ pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na+/K+ pump. The model can replicate these recordings. We propose that Na+/K+ pump activity controls the intrinsic firing mode of cerbellar Purkinje cells.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Library of Congress Subject Headings (LCSH): | Purkinje cells -- Mathematical models, Cerebellum -- Mathematical models | ||||
Journal or Publication Title: | PLoS ONE | ||||
Publisher: | PLOS | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 20 December 2012 | ||||
Dates: |
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Volume: | Vol.7 | ||||
Number: | No.12 | ||||
Page Range: | e51169 | ||||
DOI: | 10.1371/journal.pone.0051169 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | Medical Research Council (Great Britain) (MRC) |
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