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Neural correlates of movement generation in the 'at-risk mental state'

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Broome, Matthew R., Matthiasson, P., Fusar-Poli, Paolo, Woolley, J. B., Johns, L. C., Tabraham, P., Bramon, E., Valmaggia, L., Williams, S. C. R., Brammer, M. J., Chitnis, X. and McGuire, Philip (2010) Neural correlates of movement generation in the 'at-risk mental state'. Acta Psychiatrica Scandinavica, Vol.122 (No.4). pp. 295-301. doi:10.1111/j.1600-0447.2009.01524.x ISSN 0001-690X.

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Official URL: http://dx.doi.org/10.1111/j.1600-0447.2009.01524.x

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Abstract

Objective:

People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.

Method:

Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.

Results:

During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.

Conclusion:

The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Acta Psychiatrica Scandinavica
Publisher: Wiley-Blackwell Publishing, Inc.
ISSN: 0001-690X
Official Date: October 2010
Dates:
DateEvent
October 2010Published
Volume: Vol.122
Number: No.4
Number of Pages: 7
Page Range: pp. 295-301
DOI: 10.1111/j.1600-0447.2009.01524.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Guy's and St Thomas' Charitable Foundation, South London and Maudsley NHS Trust

Data sourced from Thomson Reuters' Web of Knowledge

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