Neural correlates of movement generation in the 'at-risk mental state'
Broome, Matthew R., Matthiasson, P., Fusar-Poli, Paolo, Woolley, J. B., Johns, L. C., Tabraham, P., Bramon, E., Valmaggia, L., Williams, S. C. R., Brammer, M. J., Chitnis, X. and McGuire, Philip. (2010) Neural correlates of movement generation in the 'at-risk mental state'. Acta Psychiatrica Scandinavica, Vol.122 (No.4). pp. 295-301. ISSN 0001-690XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1600-0447.2009.01524.x
Objective: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task. Method: Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm. Results: During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group. Conclusion: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Acta Psychiatrica Scandinavica|
|Publisher:||Wiley-Blackwell Publishing, Inc.|
|Number of Pages:||7|
|Page Range:||pp. 295-301|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Guy's and St Thomas' Charitable Foundation, South London and Maudsley NHS Trust|
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