Neural correlates of movement generation in the 'at-risk mental state'
Broome, Matthew R., Matthiasson, P., Fusar-Poli, Paolo, Woolley, J. B., Johns, L. C., Tabraham, P., Bramon, E., Valmaggia, L., Williams, S. C. R., Brammer, M. J., Chitnis, X. and McGuire, Philip. (2010) Neural correlates of movement generation in the 'at-risk mental state'. Acta Psychiatrica Scandinavica, Vol.122 (No.4). pp. 295-301. ISSN 0001-690XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1600-0447.2009.01524.x
People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.
Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.
During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.
The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Acta Psychiatrica Scandinavica|
|Publisher:||Wiley-Blackwell Publishing, Inc.|
|Official Date:||October 2010|
|Number of Pages:||7|
|Page Range:||pp. 295-301|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Guy's and St Thomas' Charitable Foundation, South London and Maudsley NHS Trust|
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