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Neural correlates of movement generation in the 'at-risk mental state'
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Broome, Matthew R., Matthiasson, P., Fusar-Poli, Paolo, Woolley, J. B., Johns, L. C., Tabraham, P., Bramon, E., Valmaggia, L., Williams, S. C. R., Brammer, M. J., Chitnis, X. and McGuire, Philip (2010) Neural correlates of movement generation in the 'at-risk mental state'. Acta Psychiatrica Scandinavica, Vol.122 (No.4). pp. 295-301. doi:10.1111/j.1600-0447.2009.01524.x ISSN 0001-690X.
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Official URL: http://dx.doi.org/10.1111/j.1600-0447.2009.01524.x
Abstract
Objective:
People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.
Method:
Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.
Results:
During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.
Conclusion:
The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Acta Psychiatrica Scandinavica | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISSN: | 0001-690X | ||||
| Official Date: | October 2010 | ||||
| Dates: |
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| Volume: | Vol.122 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 295-301 | ||||
| DOI: | 10.1111/j.1600-0447.2009.01524.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Guy's and St Thomas' Charitable Foundation, South London and Maudsley NHS Trust |
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