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Synthesis and evaluation of partly fluorinated polyelectrolytes as components in 19F MRI-detectable nanoparticles
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Nurmi, Leena, Peng, Hui, Seppala, Jukka, Haddleton, David M., Blakey, Idriss and Whittaker, Andrew K.. (2010) Synthesis and evaluation of partly fluorinated polyelectrolytes as components in 19F MRI-detectable nanoparticles. Polymer Chemistry, Vol.1 (No.7). pp. 1039-1047. ISSN 1759-9954
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Official URL: http://dx.doi.org/10.1039/c0py00035c
Abstract
A series of partly fluorinated polyelectrolytes were synthesized by transition metal mediated living radical polymerization and evaluated for their applicability as corona-forming components in F-19 MRI-detectable nanoparticles in aqueous solutions. The polymers were statistical and block copolymers of trifluoroethyl methacrylate (TFEMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). The polymers were either directly dissolved in water (statistical copolymers), or assembled into aqueous nanoparticles with PTFEMA cores and P(TFEMA-co-DMAEMA) coronas (block copolymers). The polymer composition, polymer charge density, solution ionic strength and solution pH were varied. The F-19 spin-lattice (T-1) and spin-spin (T-2) relaxation times and F-19 image intensities of solutions of the polymers were measured and related to polymer structure and aqueous conformation. The F-19 NMR T-2 relaxation times were found to be highly indicative of the F-19 imaging performance. Maintaining sufficient mobility of the F-19 nuclei was important for obtaining images of high intensity. F-19 mobility could be increased by preventing their aggregation in water by exploiting electrostatic repulsion between monomer units.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Chemistry |
| Journal or Publication Title: | Polymer Chemistry |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1759-9954 |
| Date: | September 2010 |
| Volume: | Vol.1 |
| Number: | No.7 |
| Number of Pages: | 9 |
| Page Range: | pp. 1039-1047 |
| Identification Number: | 10.1039/c0py00035c |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Graduate School in Chemical Engineering (Finland), Queensland Government, NCRIS Australian National Fabrication Facility |
| URI: | http://wrap.warwick.ac.uk/id/eprint/5261 |
Data sourced from Thomson Reuters' Web of Knowledge
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