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Cytokinesis microtubule organisers at a glance

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Lee, K. Y., Davies, T. and Mishima, Masanori (2012) Cytokinesis microtubule organisers at a glance. Journal of Cell Science, Vol.125 (No.15). pp. 3495-3500. doi:10.1242/jcs.094672

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Official URL: http://dx.doi.org/10.1242/jcs.094672

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Abstract

Cytokinesis is a fundamental step of cell proliferation, and its high-fidelity completion is crucial for stable maintenance of the genome (Ganem et al., 2007; Lacroix and Maddox, 2012). Anti-parallel microtubule bundle structures such as the central spindle and the midbody play various important roles throughout cytokinesis, from positioning of cleavage furrow to final separation of the two daughter cells (Barr and Gruneberg, 2007; Glotzer, 2009; Fededa and Gerlich, 2012). Although a large number of different factors that are important for abscission, including membrane trafficking machinery, localise to the midzone during cytokinesis (Caballe and Martin-Serrano, 2011; Guizetti and Gerlich, 2010; Neto and Gould, 2011), here we focus on the current understanding of protein–protein interactions between microtubule organisers and their regulators that form cytokinetic microtubule structures.

Item Type: Journal Item
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Journal of Cell Science
Publisher: The Company of Biologists Ltd.
ISSN: 0021-9533
Official Date: 1 August 2012
Dates:
DateEvent
1 August 2012Published
Volume: Vol.125
Number: No.15
Page Range: pp. 3495-3500
DOI: 10.1242/jcs.094672
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Data sourced from Thomson Reuters' Web of Knowledge

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