Quinnell, Rupert J., Carson, Connor, Reithinger, Richard, Garcez, Lourdes M. and Courtenay, Orin (2013) Evaluation of rK39 rapid diagnostic tests for canine visceral leishmaniasis : longitudinal study and meta-analysis. PLoS Neglected Tropical Diseases, Vol.7 (No.1). e1992. doi:10.1371/journal.pntd.0001992

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Abstract

Canine visceral leishmaniasis is a vector-borne disease caused by the intracellular parasite Leishmania infantum. It is an important veterinary disease, and dogs are also the main animal reservoir for human infection. The disease is widespread in the Mediterranean area, and parts of Asia and South and Central America, and is potentially fatal in both dogs and humans unless treated. Diagnosis of canine infections requires serological or molecular tests. Detection of infection in dogs is important prior to treatment, and in epidemiological studies and control programmes, and a sensitive and specific rapid diagnostic test would be very useful. Rapid diagnostic tests (RDTs) have been developed, but their diagnostic performance has been reported to be variable. We evaluated the sensitivity of a RDT based on serological detection of the rK39 antigen in a cohort of naturally infected Brazilian dogs. The sensitivity of the test to detect infection was relatively low, but increased with time since infection and the severity of infection. We then carried out a meta-analysis of published studies of rK39 RDTs, evaluating the sensitivity to detect disease and infection. The results suggest that rK39 RDTs may be useful in a veterinary clinical setting, but the sensitivity to detect infection is too low for operational control programmes.

Item Type:	Journal Article
Subjects:	Q Science > QL Zoology
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Leishmaniasis -- Diagnosis, Dogs -- Diseases -- Diagnosis
Journal or Publication Title:	PLoS Neglected Tropical Diseases
Publisher:	Public Library of Science
ISSN:	1935-2727
Official Date:	January 2013
Dates:	Date Event January 2013 Published
Date of first compliant deposit:	23 December 2015
Volume:	Vol.7
Number:	No.1
Page Range:	e1992
DOI:	10.1371/journal.pntd.0001992
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Wellcome Trust (London, England), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	036365 (WT), 069169 (WT)

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