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Evaluation of rK39 rapid diagnostic tests for canine visceral leishmaniasis : longitudinal study and meta-analysis
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Quinnell, Rupert J., Carson, Connor, Reithinger, Richard, Garcez, Lourdes M. and Courtenay, Orin (2013) Evaluation of rK39 rapid diagnostic tests for canine visceral leishmaniasis : longitudinal study and meta-analysis. PLoS Neglected Tropical Diseases, Vol.7 (No.1). e1992. doi:10.1371/journal.pntd.0001992 ISSN 1935-2727.
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Official URL: http://dx.doi.org/10.1371/journal.pntd.0001992
Abstract
Canine visceral leishmaniasis is a vector-borne disease caused by the intracellular parasite Leishmania infantum. It is an important veterinary disease, and dogs are also the main animal reservoir for human infection. The disease is widespread in the Mediterranean area, and parts of Asia and South and Central America, and is potentially fatal in both dogs and humans unless treated. Diagnosis of canine infections requires serological or molecular tests. Detection of infection in dogs is important prior to treatment, and in epidemiological studies and control programmes, and a sensitive and specific rapid diagnostic test would be very useful. Rapid diagnostic tests (RDTs) have been developed, but their diagnostic performance has been reported to be variable. We evaluated the sensitivity of a RDT based on serological detection of the rK39 antigen in a cohort of naturally infected Brazilian dogs. The sensitivity of the test to detect infection was relatively low, but increased with time since infection and the severity of infection. We then carried out a meta-analysis of published studies of rK39 RDTs, evaluating the sensitivity to detect disease and infection. The results suggest that rK39 RDTs may be useful in a veterinary clinical setting, but the sensitivity to detect infection is too low for operational control programmes.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QL Zoology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Leishmaniasis -- Diagnosis, Dogs -- Diseases -- Diagnosis | ||||
Journal or Publication Title: | PLoS Neglected Tropical Diseases | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1935-2727 | ||||
Official Date: | January 2013 | ||||
Dates: |
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Volume: | Vol.7 | ||||
Number: | No.1 | ||||
Page Range: | e1992 | ||||
DOI: | 10.1371/journal.pntd.0001992 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | Wellcome Trust (London, England), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
Grant number: | 036365 (WT), 069169 (WT) |
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