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Drechsler, Hauke and McAinsh, Andrew D. (2012) Exotic mitotic mechanisms. Open Biology, Vol.2 . Article number 120140. doi:10.1098/rsob.120140 ISSN 2046-2441.
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Official URL: http://dx.doi.org/10.1098/rsob.120140
Abstract
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Eukaryotic cells, Mitosis | ||||
Journal or Publication Title: | Open Biology | ||||
Publisher: | The Royal Society Publishing | ||||
ISSN: | 2046-2441 | ||||
Official Date: | December 2012 | ||||
Dates: |
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Volume: | Vol.2 | ||||
Page Range: | Article number 120140 | ||||
DOI: | 10.1098/rsob.120140 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Marie Curie Cancer Care | ||||
Grant number: | BB/I021353/1 (BBSRC) |
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