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Causes and consequences of ribonucleotide incorporation into nuclear DNA
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Dalgaard, Jacob Z. (2012) Causes and consequences of ribonucleotide incorporation into nuclear DNA. Trends in Genetics, Vol.28 (No.12). pp. 592-597. doi:10.1016/j.tig.2012.07.008 ISSN 0168-9525.
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Official URL: http://dx.doi.org/10.1016/j.tig.2012.07.008
Abstract
Intuitively one would not expect that ribonucleotides are incorporated into nuclear DNA beyond their role in priming Okazaki fragments, nor that such incorporation would be functional. However, several recent studies have shown that not only are ribonucleotides present in the nuclear DNA, but that they can be incorporated by at least two different mechanisms: random ‘mis’-incorporation of ribonucleotides, which occurs at a surprisingly high frequency; and site-specific incorporation at a stalled fork. Importantly, in the latter case, the ribonucleotides have been shown to have a biological function – acting to initiate a replication-coupled recombination event mediating a cell type change. Traditionally, it has been thought that ‘random’ ribonucleotide incorporation causes genetic instability, but new evidence suggests there may be a fine balance between mechanisms preventing and incorporating ribonucleotides into genomic DNA. Indeed, genomic ribonucleotides might have diverse roles affecting genetic stability, DNA damage repair, heterochromatin formation, cellular differentiation, and development.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Trends in Genetics | ||||
| Publisher: | Elsevier Ltd. * Trends Journals | ||||
| ISSN: | 0168-9525 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Vol.28 | ||||
| Number: | No.12 | ||||
| Page Range: | pp. 592-597 | ||||
| DOI: | 10.1016/j.tig.2012.07.008 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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