The Library
Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity
Tools
Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin, McLaren, James E., Smart, Kathryn, Hindley, James P., Bridgeman, Hayley M., Berg, Hugo van den , Price, D. A., Ager, Ann, Wooldridge, Linda, Godkin, Andrew and Gallimore, Awen M. (2012) Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology, Volume 42 (Number 12). pp. 3235-3242. doi:10.1002/eji.201242575 ISSN 0014-2980.
|
Text
WRAP_Berg_eji2449 %281%29.pdf - Published Version Download (1226Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/eji.201242575
Abstract
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+ T-cell memory. Using a model of influenza virus infection, where loss of protective CD8+ T-cell immunity was observed 6 months postinfection, we found no decline in antigen-specific T-cell numbers or migration to the site of secondary infection. There was, however, a large reduction in antigen-specific CD8+ T-cell degranulation, cytokine secretion, and polyfunctionality. A profound loss of high-avidity T cells over time indicated that failure to confer protective immunity resulted from the inferior functional capacity of remaining low avidity cells. These data imply that high-avidity central memory T cells wane with declining antigen levels, leaving lower avidity T cells with reduced functional capabilities.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology > QR180 Immunology |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||
Library of Congress Subject Headings (LCSH): | Influenza , Cell-mediated cytotoxicity, Vaccination | ||||
Journal or Publication Title: | European Journal of Immunology | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 0014-2980 | ||||
Official Date: | 2012 | ||||
Dates: |
|
||||
Volume: | Volume 42 | ||||
Number: | Number 12 | ||||
Page Range: | pp. 3235-3242 | ||||
DOI: | 10.1002/eji.201242575 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | Wellcome Trust (London, England) | ||||
Grant number: | WT082249MA, 086983/Z/08/Z (WT) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year