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Effects of exenatide and liraglutide on heart rate, blood pressure and body weight : systematic review and meta-analysis

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Robinson, Louise E., Holt, Tim A., Rees, Karen, Randeva, Harpal S. and O'Hare, J. Paul (2013) Effects of exenatide and liraglutide on heart rate, blood pressure and body weight : systematic review and meta-analysis. BMJ Open, Vol.3 (No.1). Article no. e001986. doi:10.1136/bmjopen-2012-001986 ISSN 2044-6055.

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Official URL: http://dx.doi.org/10.1136/bmjopen-2012-001986

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Abstract

Objectives: To synthesise current evidence for the effects of exenatide and liraglutide on heart rate, blood pressure and body weight.

Design: Meta-analysis of available data from randomised controlled trials comparing Glucagon-like peptide-1 (GLP-1) analogues with placebo, active antidiabetic drug therapy or lifestyle intervention.

Participants: Patients with type 2 diabetes.

Outcome measures: Weighted mean differences between trial arms for changes in heart rate, blood pressure and body weight, after a minimum of 12-week follow-up.

Results: 32 trials were included. Overall, GLP-1 agonists increased the heart rate by 1.86 beats/min (bpm) (95% CI 0.85 to 2.87) versus placebo and 1.90 bpm (1.30 to 2.50) versus active control. This effect was more evident for liraglutide and exenatide long-acting release than for exenatide twice daily. GLP-1 agonists decreased systolic blood pressure by −1.79 mm Hg (−2.94 to −0.64) and −2.39 mm Hg (−3.35 to −1.42) compared to placebo and active control, respectively. Reduction in diastolic blood pressure failed to reach statistical significance (−0.54 mm Hg (−1.15 to 0.07) vs placebo and −0.50 mm Hg (−1.24 to 0.24) vs active control). Body weight decreased by −3.31 kg (−4.05 to −2.57) compared to active control, but by only −1.22 kg (−1.51 to −0.93) compared to placebo.

Conclusions: GLP-1 analogues are associated with a small increase in heart rate and modest reductions in body weight and blood pressure. Mechanisms underlying the rise in heart rate require further investigation.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Systematic reviews (Medical research), Meta-analysis, Peptide drugs -- Testing, Non-insulin-dependent diabetes -- Treatment -- Research, Heart -- Effect of drugs on
Journal or Publication Title: BMJ Open
Publisher: BMJ
ISSN: 2044-6055
Official Date: 2013
Dates:
DateEvent
2013Published
Volume: Vol.3
Number: No.1
Page Range: Article no. e001986
DOI: 10.1136/bmjopen-2012-001986
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 23 December 2015
Date of first compliant Open Access: 23 December 2015

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