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Effects of exenatide and liraglutide on heart rate, blood pressure and body weight : systematic review and meta-analysis
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Robinson, Louise E., Holt, Tim A., Rees, Karen, Randeva, Harpal S. and O'Hare, J. Paul (2013) Effects of exenatide and liraglutide on heart rate, blood pressure and body weight : systematic review and meta-analysis. BMJ Open, Vol.3 (No.1). Article no. e001986. doi:10.1136/bmjopen-2012-001986 ISSN 2044-6055.
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Official URL: http://dx.doi.org/10.1136/bmjopen-2012-001986
Abstract
Objectives: To synthesise current evidence for the effects of exenatide and liraglutide on heart rate, blood pressure and body weight.
Design: Meta-analysis of available data from randomised controlled trials comparing Glucagon-like peptide-1 (GLP-1) analogues with placebo, active antidiabetic drug therapy or lifestyle intervention.
Participants: Patients with type 2 diabetes.
Outcome measures: Weighted mean differences between trial arms for changes in heart rate, blood pressure and body weight, after a minimum of 12-week follow-up.
Results: 32 trials were included. Overall, GLP-1 agonists increased the heart rate by 1.86 beats/min (bpm) (95% CI 0.85 to 2.87) versus placebo and 1.90 bpm (1.30 to 2.50) versus active control. This effect was more evident for liraglutide and exenatide long-acting release than for exenatide twice daily. GLP-1 agonists decreased systolic blood pressure by −1.79 mm Hg (−2.94 to −0.64) and −2.39 mm Hg (−3.35 to −1.42) compared to placebo and active control, respectively. Reduction in diastolic blood pressure failed to reach statistical significance (−0.54 mm Hg (−1.15 to 0.07) vs placebo and −0.50 mm Hg (−1.24 to 0.24) vs active control). Body weight decreased by −3.31 kg (−4.05 to −2.57) compared to active control, but by only −1.22 kg (−1.51 to −0.93) compared to placebo.
Conclusions: GLP-1 analogues are associated with a small increase in heart rate and modest reductions in body weight and blood pressure. Mechanisms underlying the rise in heart rate require further investigation.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Systematic reviews (Medical research), Meta-analysis, Peptide drugs -- Testing, Non-insulin-dependent diabetes -- Treatment -- Research, Heart -- Effect of drugs on | ||||
| Journal or Publication Title: | BMJ Open | ||||
| Publisher: | BMJ | ||||
| ISSN: | 2044-6055 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Volume: | Vol.3 | ||||
| Number: | No.1 | ||||
| Page Range: | Article no. e001986 | ||||
| DOI: | 10.1136/bmjopen-2012-001986 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Date of first compliant deposit: | 23 December 2015 | ||||
| Date of first compliant Open Access: | 23 December 2015 |
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