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Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction

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Andrikopoulos, George K., Grammatopoulos, Dimitris K., Tzeis, Stylianos E., Zervou, Sevasti I., Richter, Dimitris J., Zairis, Michalis N., Gialafos, Elias J., Sakellariou, Dimitris C., Foussas, Stefanos G., Manolis, Antonis S., Stefanadis, Christodoulos I., Toutouzas, Pavlos K. and Hillhouse, Edward W.. (2008) Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction. BMC Medical Genetics, Vol.9 (No.43). ISSN 1471-2350

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Official URL: http://dx.doi.org/10.1186/1471-2350-9-43

Abstract

Background: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI. Methods: We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population. Results: The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77–1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63–2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29–4.04, P = 0.908). Conclusion: In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AMI

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Myocardial infarction, Coronary heart disease, Genes
Journal or Publication Title:	BMC Medical Genetics
Publisher:	BioMed Central Ltd.
ISSN:	1471-2350
Date:	21 May 2008
Volume:	Vol.9
Number:	No.43
Number of Pages:	6
Identification Number:	10.1186/1471-2350-9-43
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	European Society of Cardiology , Hellenic Heart Foundation
Grant number:	Research fellowships 1999– 2000 and 1998–1999 (ESC) , Research Fellowship, 1998–1999 (HHF)
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URI:	http://wrap.warwick.ac.uk/id/eprint/530