1. Veldman BA, Spiering W, Doevendans PA, Vervoort G, Kroon AA, de
Leeuw PW, Smits P: The Glu298Asp polymorphism of the
NOS3 gene as a determinant of the baseline production of
nitric oxide. J Hypertens 2002, 20(10):2023-7.
2. Wang XL, Sim AS, Wang MX, Murrell GA, Trudinger B, Wang J: Genotype
dependent and cigarette specific effects on endothelial
nitric oxide synthase gene expression and enzyme activity.
FEBS Lett 2000, 471:45-50.
3. Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J:
Intracellular processing of endothelial nitric oxide synthase
isoforms associated with differences in severity of cardiopulmonary
diseases: cleavage of proteins with aspartate vs.
glutamate at position 298. Proc Natl Acad Sci 2000, 97(6):2832-5.
4. Fairchild TA, Fulton D, Fontana JT, Gratton JP, McCabe TJ, Sessa WC:
Acidic hydrolysis as a mechanism for the cleavage of the
Glu(298)3Asp variant of human endothelial nitric-oxide synthase.
J Biol Chem 2001, 276:26674-26679.
5. McDonald DM, Alp NJ, Channon KM: Functional comparison of
the endothelial nitric oxide synthase Glu298Asp polymorphic
variants in human endothelial cells. Pharmacogenetics 2004,
14(12):831-9.
6. Chang K, Baek SH, Seung KB, Kim PJ, Ihm SH, Chae JS, Kim JH, Hong
SJ, Choi KB: The Glu298Asp polymorphism in the endothelial
nitric oxide synthase gene is strongly associated with coronary
spasm. Coron Artery Dis 2003, 14(4):293-9.
7. Philip I, Plantefeve G, Vuillaumier-Barrot S, Vicaut E, LeMarie C, Henrion
, Poirier O, Levy BI, Desmonts JM, Durant G, Benessiano J:
G894T polymorphism in the endothelial nitric oxide synthase
gene is associated with an enhanced vascular responsiveness
to phenylephrine. Circulation 1999, 99:3096-3098.
8. McNamara DM, Holubkov R, Postava L, Ramani R, Janosko K, Mathier
M, MacGowan GA, Murali S, Feldman AM, London B: Effect of the
Asp298 variant of endothelial nitric oxide synthase on survival
for patients with congestive heart failure. Circulation
2003, 107(12):1598-602.
9. Hingorani AD, Liang CF, Fatibene J, Lyon A, Monteith S, Parsons A,
Haydock S, Hopper RV, Stephens NG, O'Shaughnessy KM, Brown MJ:
A common variant of the endothelial nitric oxide synthase
(Glu298->Asp) is a major risk factor for coronary artery disease
in the UK. Circulation 1999, 100:1515-20.
10. Antoniades C, Tousoulis D, Vasiliadou C, Pitsavos C, Chrysochoou C,
Panagiotakos D, Tentolouris C, Marinou K, Koumallos N, Stefanadis
C: Genetic polymorphism on endothelial nitric oxide synthase
affects endothelial activation and inflammatory
response during the acute phase of myocardial infarction. J
Am Coll Cardiol 2005, 46(6):1101-9.
11. Lembo G, De Luca N, Battagli C, Iovino G, Aretini A, Musicco M, Frati
G, Pompeo FVecchione C, Trimarco B: A common variant of
endothelial nitric oxide synthase (Glu298Asp) is an independent
risk factor for carotid atherosclerosis. Stroke 2001,
32(3):735-40.
12. Paradossi U, Ciofini E, Clerico A, Botto N, Biagini A, Colombo MG:
Endothelial function and carotid intima-media thickness in
young healthy subjects among endothelial nitric oxide synthase
Glu298-->Asp and T-786-->C polymorphisms. Stroke
2004, 35(6):1305-9.
13. Gomma AH, Elrayess MA, Knight CJ, Hawe E, Fox KM, Humphries SE:
The endothelial nitric oxide synthase (Glu298Asp and -
786T>C) gene polymorphisms are associated with coronary
in-stent restenosis. Eur Heart J 2002, 23(24):1955-62.
14. Granath B, Taylor RR, van Bockxmeer FM, Mamotte CD: Lack of
evidence for association between endothelial nitric oxide
synthase gene polymorphisms and coronary artery disease
in the Australian Caucasian population. J Cardiovasc Risk 2001,
8(4):235-41.
15. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H,
Sone T, Tanaka M, Yokota M: Prediction of the risk of myocardial
infarction from polymorphisms in candidate genes. N
Engl J Med 2002, 347:1916-23.
16. Spence MS, McGlinchey PG, Patterson CC, Allen AR, Murphy G,
Bayraktutan U, Fogarty DG, Evans AE, McKeown PP: Endothelial
nitric oxide synthase gene polymorphism and ischemic heart
disease. Am Heart J 2004, 148(5):847-51.
17. Zhang C, Lopez-Ridaura R, Hunter DJ, Rifai N, Hu FB: Common
variants of the endothelial nitric oxide synthase gene and the
risk of coronary heart disease among U.S. diabetic men. Diabetes
2006, 55(7):2140-7.
18. Andrikopoulos GK, Richter DJ, Needham EW, Tzeis SE, Zairis MN,
Gialafos EJ, Vogiatzi PG, Papasteriadis EG, Kardaras FG, Foussas SG,
Gialafos JE, Stefanadis CI, Toutouzas PK, Mattu RK, GEMIG study
investigators: The paradoxical association of common polymorphisms
of the renin-angiotensin system genes with risk
of myocardial infarction. Eur J Cardiovasc Prev Rehabil 2004,
11(6):477-83.
19. Andrikopoulos GK, Richter DJ, Needham EW, Zairis MN, Karabinos
EN, Gialafos EJ, Dilaveris PE, Paravolidakis KE, Kappos KG, Papasteriadis
EG, Kardaras FG, Foussas SG, Stefanadis CI, Gialafos JE, Mattu
RK, Toutouzas PK, GEMIG Study Investigators: Association of the
ile405val mutation in cholesteryl ester transfer protein gene
with risk of acute myocardial infarction. Heart 2004,
90(11):1336-7.
20. Andrikopoulos GK, Tzeis SM, Needham EW, Richter DJ, Zairis MN,
Gialafos EJ, Kardaras FG, Foussas SG, Stefanadis CI, Toutouzas PK,
Mattu R, GEMIG study investigators: Lack of association between
common polymorphisms in genes of the renin-angiotensin
system and mortality after myocardial infarction. Cardiology
2005, 103(4):185-8.
21. Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C, Toutouzas
P: Risk stratification of coronary heart disease through established
and emerging lifestyle factors in a Mediterranean population:
CARDIO2000 epidemiological study. J Cardiovasc Risk
2001, 8(6):329-35.
22. Andrikopoulos GK, Richter DJ, Dilaveris PE, Pipilis A, Zaharoulis A,
Gialafos JE, Toutouzas PK, Chimonas ET: In-hospital mortality of
habitual cigarette smokers after acute myocardial infarction.
The smoker's paradox in a countrywide study. Eur Heart
J 2001, 22:776-784.
23. Marsden PA, Heng HH, Scherer SW, Stewart RJ, Hall AV, Shi XM,
Tsui LC, Schappert KT: Structure and chromosomal localization
of the human constitutive endothelial nitric oxide synthase.
J Biol Chem 1993, 268:17478-17488.
24. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton
R, Cheng S, Shuldiner AR: Unique lipoprotein phenotype and
genotype associated with exceptional longevity. JAMA 2003,
290(15):2030-40.
25. Andrikopoulos GK, Richter DJ: Genetic factors in exceptional
longevity. JAMA 2004, 291(8):941-2.
26. Napoli C, de Nigris F, Williams-Ignarro S, Pignalosa O, Sica V, Ignarro
LJ: Nitric oxide and atherosclerosis: An update. Nitric Oxide in
press. 2006 Apr 15;
27. Golser R, Gorren AC, Mayer B, Schmidt K: Functional characterization
of Glu298Asp mutant human endothelial nitric oxide
synthase purified from a yeast expression system. Nitric Oxide
2003, 8(1):7-14.
28. Dosenko VE, Zagoriy VY, Haytovich NV, Gordok OA, Moibenko AA:
Allelic polymorphism of endothelial NO-synthase gene and
its functional manifestations. Acta Biochim Pol 2006,
53(2):299-302.
29. Dedio J, Konig P, Wohlfart P, Schroeder C, Kummer W, Muller-Esterl
W: NOSIP, a novel modulator of endothelial nitric oxide synthase
activity. FASEB J 2001, 15:79-89.
30. Garcia-Cardena G, Martasek P, Masters BS, Skidd PM, Couet J, Li S,
Lisanti MP, Sessa WC: Dissecting the interaction between nitric
oxide synthase (NOS) and caveolin. Functional significance
of the NOS caveolin binding domain in vivo. J Biol Chem 1997,
272:25437-25440.
31. Casas JP, Bautista LE, Humphries SE, Hingorani AD: Endothelial
nitric oxide synthase genotype and ischemic heart disease:
meta-analysis of 26 studies involving 23 028 subjects. Circulation
2004, 109:1359-1365.
32. Cam SF, Sekuri C, Tengiz I, Ercan E, Sagcan A, Akin M, Berdeli A: The
G894T polymorphism on endothelial nitric oxide synthase
gene is associated with premature coronary artery disease in
a Turkish population. Thromb Res 2005, 116(4):287-92.
33. Gardemann A, Lohre J, Cayci S, Katz N, Tillmanns H, Haberbosch W:
The T allele of the missense Glu(298)Asp endothelial nitric
oxide synthase gene polymorphism is associated with coronary
heart disease in younger individuals with high atherosclerotic
risk profile. Atherosclerosis 2002, 160(1):167-75.
34. Gorchakova O, Koch W, Beckerath N, Mehilli J, Schomig A, Kastrati
A: Association of a genetic variant of endothelial nitric oxide
synthase with the 1 year clinical outcome after coronary
stent placement. Eur Heart J 2003, 24:820-827.