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The tomato Prf complex is a molecular trap for bacterial effectors based on Pto transphosphorylation
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Ntoukakis, Vardis, Balmuth, Alexi L., Mucyn, Tatiana S., Gutierrez, Jose R., Jones, Alexandra M. and Rathjen, John P. (2013) The tomato Prf complex is a molecular trap for bacterial effectors based on Pto transphosphorylation. PLoS Pathogens, Vol.9 (No.1). Article no. e1003123. doi:10.1371/journal.ppat.1003123 ISSN 1553-7374.
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Official URL: http://dx.doi.org/10.1371/journal.ppat.1003123
Abstract
The bacteria Pseudomonas syringae is a pathogen of many crop species and one of the model pathogens for studying plant and bacterial arms race coevolution. In the current model, plants perceive bacteria pathogens via plasma membrane receptors, and recognition leads to the activation of general defenses. In turn, bacteria inject proteins called effectors into the plant cell to prevent the activation of immune responses. AvrPto and AvrPtoB are two such proteins that inhibit multiple plant kinases. The tomato plant has reacted to these effectors by the evolution of a cytoplasmic resistance complex. This complex is compromised of two proteins, Prf and Pto kinase, and is capable of recognizing the effector proteins. How the Pto kinase is able to avoid inhibition by the effector proteins is currently unknown. Our data shows how the tomato plant utilizes dimerization of resistance proteins to gain advantage over the faster evolving bacterial pathogen. Here we illustrate that oligomerisation of Prf brings into proximity two Pto kinases allowing them to avoid inhibition by the effectors by transphosphorylation and to activate immune responses.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry S Agriculture > SB Plant culture |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Phosphates, Pseudomonas syringae, Virulence (Microbiology), Tomatoes -- Disease and pest resistance, Protein kinases | ||||
Journal or Publication Title: | PLoS Pathogens | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1553-7374 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | Vol.9 | ||||
Number: | No.1 | ||||
Page Range: | Article no. e1003123 | ||||
DOI: | 10.1371/journal.ppat.1003123 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Gatsby Charitable Foundation (GCF), Australian Research Council (ARC) | ||||
Grant number: | BB/D00456X/1 (BBSRC), FT0992129 (ARC) |
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