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Shine-Dalgarno sequence of bacteriophage T4 : GAGG prevails in early genes
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Malys, Naglis (2012) Shine-Dalgarno sequence of bacteriophage T4 : GAGG prevails in early genes. Molecular Biology Reports, Vol.39 (No.1). pp. 33-39. doi:10.1007/s11033-011-0707-4 ISSN 0301-4851.
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Official URL: http://dx.doi.org/10.1007/s11033-011-0707-4
Abstract
Translation initiation is governed by a limited number of mRNA sequence motifs within the translation initiation region (TIR). In bacteria and bacteriophages, one of the most important determinants is a Shine-Dalgarno (SD) sequence that base pairs with the anti-SD sequence GAUCACCUCCUUA localized in the 3′ end of 16S rRNA. This work assesses a diversity of TIR features in phage T4, focusing on the SD sequence, its spacing to the start codon and relationship to gene expression and essentiality patterns. Analysis shows that GAGG is predominant of all core SD motifs in T4 and its related phages, particularly in early genes. Possible implication of the RegB activity is discussed.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Molecular Biology Reports | ||||
Publisher: | Springer Netherlands | ||||
ISSN: | 0301-4851 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.39 | ||||
Number: | No.1 | ||||
Page Range: | pp. 33-39 | ||||
DOI: | 10.1007/s11033-011-0707-4 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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