Mattu, Harman and Randeva, Harpal S. (2013) Role of adipokines in cardiovascular disease. Journal of Endocrinology, Vol.216 (No.1). T17-T36. doi:10.1530/JOE-12-0232

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Abstract

The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose tissue. It is now recognised to be a metabolically active endocrine organ, producing important chemical messengers – adipokines and cytokines (adipocytokines). The search for new adipocytokines or adipokines gained added fervour with the prospect of the reconciliation between cardiovascular diseases (CVDs), obesity and metabolic syndrome.
The role these new chemical messengers play in inflammation, satiety, metabolism and cardiac function has paved the way for new research and theories examining the effects they have on (in this case) CVD. Adipokines are involved in a ‘good–bad’, yin–yang homoeostatic balance whereby there are substantial benefits: cardioprotection, promoting endothelial
function, angiogenesis and reducing hypertension, atherosclerosis and inflammation. The flip side may show contrasting, detrimental effects in aggravating these cardiac parameters

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Endocrinology
Publisher:	Society for Endocrinology
ISSN:	0022-0795
Official Date:	2013
Dates:	Date Event 2013 Published
Volume:	Vol.216
Number:	No.1
Page Range:	T17-T36
DOI:	10.1530/JOE-12-0232
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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