Soman, Sherman, Ashok, Dhandapani, Connolly, Sally A., Cordell, Samantha J. , Taylor, Chris J. and Campbell, David I. (2010) Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine. Drugs in R & D, Volume 10 (Number 4). pp. 213-217. doi:10.2165/11539930-000000000-00000

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Abstract

Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns as forerunners for hematologic malig-nancies. This study gives a statistical description of factors influencing the relationship between MCV and WBC in children with inflammatory bowel disease treated with azathioprine. We found that leukopenia preceded macro¬cytosis. Macrocytosis is therefore not a good predictor of leukopenia. Further studies will be necessary to determine the subgroup of patients at increased risk of malignancies based on bone marrow response.

Item Type:	Journal Article
Subjects:	R Medicine > RB Pathology R Medicine > RJ Pediatrics R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Pediatrics -- Research, Intestines -- Diseases -- Treatment, Children -- Diseases, Hematology
Journal or Publication Title:	Drugs in R & D
Publisher:	Adis International Ltd.
ISSN:	1174-5886
Official Date:	2010
Dates:	Date Event 2010 Published
Volume:	Volume 10
Number:	Number 4
Page Range:	pp. 213-217
DOI:	10.2165/11539930-000000000-00000
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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