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Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine
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Soman, Sherman, Ashok, Dhandapani, Connolly, Sally A., Cordell, Samantha J. , Taylor, Chris J. and Campbell, David I. (2010) Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine. Drugs in R & D, Volume 10 (Number 4). pp. 213-217. doi:10.2165/11539930-000000000-00000
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WRAP_Cordell_40268_2012_Article_10040213.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (285Kb) | Preview |
Official URL: http://dx.doi.org/10.2165/11539930-000000000-00000
Abstract
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns as forerunners for hematologic malig-nancies. This study gives a statistical description of factors influencing the relationship between MCV and WBC in children with inflammatory bowel disease treated with azathioprine. We found that leukopenia preceded macro¬cytosis. Macrocytosis is therefore not a good predictor of leukopenia. Further studies will be necessary to determine the subgroup of patients at increased risk of malignancies based on bone marrow response.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RB Pathology R Medicine > RJ Pediatrics R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Library of Congress Subject Headings (LCSH): | Pediatrics -- Research, Intestines -- Diseases -- Treatment, Children -- Diseases, Hematology | ||||
| Journal or Publication Title: | Drugs in R & D | ||||
| Publisher: | Adis International Ltd. | ||||
| ISSN: | 1174-5886 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | Volume 10 | ||||
| Number: | Number 4 | ||||
| Page Range: | pp. 213-217 | ||||
| DOI: | 10.2165/11539930-000000000-00000 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
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