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Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system
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Leigh, Simon J., Gilbert, Hamish T. J., Barker, Ian A., Becker, Jan M., Richardson, Stephen M., Hoyland, Judith A., Covington, James A. and Dove, Andrew P. (2013) Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system. Biomacromolecules, Vol.14 (No.1). pp. 186-192. doi:10.1021/bm3015736
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Official URL: http://dx.doi.org/10.1021/bm3015736
Abstract
A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science > Chemistry Faculty of Science > Engineering |
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| Journal or Publication Title: | Biomacromolecules | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 1525-7797 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Volume: | Vol.14 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 186-192 | ||||
| DOI: | 10.1021/bm3015736 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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