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Dual functional ionic liquids as plasticisers and antimicrobial agents for medical polymers
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Choi, Seong Ying, Rodríguez, Héctor, Mirjafari, Arsalan, Gilpin, Deirdre F., McGrath, Stephanie, Malcolm, Karl R., Tunney, Michael M., Rogers, Robin D. and McNally, Tony (2011) Dual functional ionic liquids as plasticisers and antimicrobial agents for medical polymers. Green Chemistry, Vol.13 (No.6). pp. 1527-1535. doi:10.1039/c1gc15132k ISSN 1463-9262.
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Official URL: http://dx.doi.org/10.1039/C1GC15132K
Abstract
Contamination of medical devices with bacteria such as Meticillin resistant Staphylococcus aureus (MRSA) is of great clinical concern. Poly(vinyl chloride) is widely used in the production of medical devices, such as catheters. The flexibility of catheter tubing is derived from the addition of plasticisers. Here, we report the design of two dual functional ionic liquids, 1-ethylpyridinium docusate and tributyl(2-hydroxyethyl)phosphonium docusate, which uniquely provide a plasticising effect, and exhibit antimicrobial and antibiofilm-forming activity to a range of antibiotic resistant bacteria. The plasticisation of poly(vinyl chloride) was tailored as a function of ionic liquid concentration. The effective antimicrobial behaviour of both ionic liquids originates from the chemical structure of the anion or cation and is not limited to the length of the alkyl chain on the anion/cation. The design approach adopted will be useful in developing ionic liquids as multi-functional additives for polymers.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | Green Chemistry | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1463-9262 | ||||
Official Date: | April 2011 | ||||
Dates: |
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Volume: | Vol.13 | ||||
Number: | No.6 | ||||
Page Range: | pp. 1527-1535 | ||||
DOI: | 10.1039/c1gc15132k | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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