Mistry, Hema, Morris, S., Dyer, Matthew, Kotseva, Kornelia, Wood, David and Buxton, Martin (2012) Cost-effectiveness of a European preventive cardiology programme in primary care : a Markov modelling approach. BMJ Open, Volume 2 (Number 5). Article no. e001029. doi:10.1136/bmjopen-2012-001029 ISSN 2044-6055.

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Abstract

OBJECTIVE:
To investigate the longer-term cost-effectiveness of a nurse-coordinated preventive cardiology programme for primary prevention of cardiovascular disease (CVD) compared to routine practice from a health service perspective.
DESIGN:
A matched, paired cluster-randomised controlled trial.
SETTING:
Six pairs of general practices in six countries.
PARTICIPANTS:
1019 patients were randomised to the EUROACTION intervention programme and 1005 patients to usual care (UC) and who completed the 1-year follow-up.
OUTCOME MEASURES:
Evidence on health outcomes and costs was based on patient-level data from the study, which had a 1-year follow-up period. Future risk of CVD events was modelled, using published risk models based on patient characteristics. An individual-level Markov model for each patient was used to extrapolate beyond the end of the trial, which was populated with data from published sources. We used an 11-year time horizon and investigated the impact on the cost-effectiveness of varying the duration of the effect of the intervention beyond the end of the trial. Results are expressed as incremental cost per quality-adjusted life-year gained.
RESULTS:
Unadjusted results found the intervention to be more costly and also more effective than UC. However, after adjusting for differences in age, gender, country and baseline risk factors, the intervention was dominated by UC, but this analysis was not able to take into account the lifestyle changes in terms of diet and physical activity.
CONCLUSIONS:
Although the EUROACTION study achieved healthier lifestyle changes and improvements in management of blood pressure and lipids for patients at high risk of CVD, compared to UC, it was not possible to show, using available risk equations which do not incorporate diet and physical activity, that the intervention reduced longer-term cardiovascular risk cost-effectively. Whether or not an intervention such as that offered by EUROACTION is cost-effective requires a longer-term trial with major cardiovascular events as the outcome.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) > Warwick Evidence Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Medicine, Preventive -- Cost effectiveness, Heart -- Diseases -- Prevention, Medical care, Cost of, Markov processes, Primary care (Medicine)
Journal or Publication Title:	BMJ Open
Publisher:	BMJ
ISSN:	2044-6055
Official Date:	2012
Dates:	Date Event 2012 Published
Volume:	Volume 2
Number:	Number 5
Page Range:	Article no. e001029
DOI:	10.1136/bmjopen-2012-001029
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	24 December 2015
Date of first compliant Open Access:	24 December 2015
Funder:	AstraZeneca (Firm)

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