The Library
Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine : a randomized, double-blind phase III trial in African children and adolescents with uncomplicated plasmodium falciparum malaria
Tools
Rénia, Laurent, Premji, Zul, Umeh, Rich Enujioke, Owusu-Agyei, Seth, Esamai, Fabian, Ezedinachi, Emmanuel U., Oguche, Stephen, Borrmann, Steffen, Sowunmi, Akintunde, Duparc, Stephan, Kirby, Paula L., Pamba, Allan, Kellam, Lynda, Guiguemdé, Robert, Greenwood, Brian, Ward, S. A. and Winstanley, Peter (2009) Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine : a randomized, double-blind phase III trial in African children and adolescents with uncomplicated plasmodium falciparum malaria. PLoS One, Volume 4 (Number 8). Article no. e6682. doi:10.1371/journal.pone.0006682 ISSN 1932-6203.
|
Text
WRAP_Winstanley_journal.pone.0006682.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (608Kb) | Preview |
Official URL: http://dx.doi.org/10.1371/journal.pone.0006682
Abstract
Chlorproguanil−dapsone−artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Library of Congress Subject Headings (LCSH): | Antimalarials -- Research, Malaria -- Treatment -- Research, Clinical trials -- Africa, Malaria -- Patients -- Africa | ||||
Journal or Publication Title: | PLoS One | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 2009 | ||||
Dates: |
|
||||
Volume: | Volume 4 | ||||
Number: | Number 8 | ||||
Page Range: | Article no. e6682 | ||||
DOI: | 10.1371/journal.pone.0006682 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Deutsche Forschungsgemeinschaft (DFG) | ||||
Grant number: | SFB 544, A7 (DFG) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year