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Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m)
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Caudwell Xtreme Everest Research Group (Including: McMorrow, R. C. N., Windsor, J. S., Hart, N. D., Richards, P., Rodway, G. W., Ahuja, V. Y., O’Dwyer, M. J., Mythen, M. G. and Grocott, M. P. W.). (2012) Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). Anaesthesia (Oxford), Vol.67 (No.8). pp. 875-880. doi:10.1111/j.1365-2044.2012.07152.x ISSN 0003-2409.
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Official URL: http://dx.doi.org/10.1111/j.1365-2044.2012.07152.x
Abstract
We present a randomised, controlled, crossover trial of the Caudwell Xtreme Everest (CXE) closed circuit breathing system vs an open circuit and ambient air control in six healthy, hypoxic volunteers at rest and exercise at Everest Base Camp, at 5300 m. Compared with control, arterial oxygen saturations were improved at rest with both circuits. There was no difference in the magnitude of this improvement as both circuits restored median (IQR [range]) saturation from 75%, (69.5–78.9 [68–80]%) to > 99.8% (p = 0.028). During exercise, the CXE closed circuit improved median (IQR [range]) saturation from a baseline of 70.8% (63.8–74.5 [57–76]%) to 98.8% (96.5–100 [95–100]%) vs the open circuit improvement to 87.5%, (84.1–88.6 [82–89]%; p = 0.028). These data demonstrate the inverse relationship between supply and demand with open circuits and suggest that ambulatory closed circuits may offer twin advantages of supplying higher inspired oxygen concentrations and/or economy of gas use for exercising hypoxic adults.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Anaesthesia (Oxford) | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 0003-2409 | ||||
Official Date: | August 2012 | ||||
Dates: |
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Volume: | Vol.67 | ||||
Number: | No.8 | ||||
Page Range: | pp. 875-880 | ||||
DOI: | 10.1111/j.1365-2044.2012.07152.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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