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Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures
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Gould, Peter D., Ugarte, Nicolas, Domijan, Mirela, Costa, Maria J. (Maria João), Foreman, Julia, MacGregor, Dana, Rose, Ken, Griffiths, Jayne, Millar, A. J. (Andrew J.), Finkenstädt, Bärbel, Penfield, Steven, Rand, D. A. (David A.), Halliday, Karen J. and Hall, Anthony J. W. (2013) Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures. Molecular Systems Biology, Volume 9 . Article no. 650. doi:10.1038/msb.2013.7 ISSN 1744-4292.
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WRAP_Rand_msb20137.pdf - Published Version Available under License Creative Commons Attribution Non-commercial Share Alike. Download (712Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/msb.2013.7
Abstract
Circadian clocks exhibit ‘temperature compensation', meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis. We show that blue light is essential for this, suggesting that the effects of light and temperature interact or converge upon common targets in the circadian clock. Our data demonstrate that two cryptochrome photoreceptors differentially control circadian period and sustain rhythmicity across the physiological temperature range. In order to test the hypothesis that the targets of light regulation are sufficient to mediate temperature compensation, we constructed a temperature-compensated clock model by adding passive temperature effects into only the light-sensitive processes in the model. Remarkably, this model was not only capable of full temperature compensation and consistent with mRNA profiles across a temperature range, but also predicted the temperature-dependent change in the level of LATE ELONGATED HYPOCOTYL, a key clock protein. Our analysis provides a systems-level understanding of period control in the plant circadian oscillator.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Plant molecular genetics, Molecular biology -- Research, Plant molecular biology, Plants -- Metabolism, Circadian rhythms, Biological rhythms in plants | ||||
Journal or Publication Title: | Molecular Systems Biology | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1744-4292 | ||||
Official Date: | March 2013 | ||||
Dates: |
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Volume: | Volume 9 | ||||
Page Range: | Article no. 650 | ||||
DOI: | 10.1038/msb.2013.7 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), University of Liverpool | ||||
Grant number: | BB/F005237/1, BB/F5005318/1, BB/F005261/1, BB/F005296/1 (BBSRC) |
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