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The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria
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Wellington, E. M. H., Boxall, Alistair B. A., Cross, Paul, Feil, Edward J., Gaze, William H., Hawkey, P. M., Johnson-Rollings, Ashley S., Jones, Davey L., Lee, Nick, Otten, Wilfred, Thomas, Christopher M. and Williams, A. Prysor (2013) The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria. The Lancet Infectious Diseases, Vol.13 (No.2). pp. 155-165. doi:10.1016/S1473-3099(12)70317-1 ISSN 1473-3099.
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Official URL: http://dx.doi.org/10.1016/S1473-3099(12)70317-1
Abstract
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | The Lancet Infectious Diseases | ||||
| Publisher: | The Lancet Publishing Group | ||||
| ISSN: | 1473-3099 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Volume: | Vol.13 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 155-165 | ||||
| DOI: | 10.1016/S1473-3099(12)70317-1 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) |
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