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Herbicide mixtures at high doses slow the evolution of resistance in experimentally evolving populations of Chlamydomonas reinhardtii

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Lagator, Mato, Vogwill, Tom, Mead, A. (Andrew), Colegrave, Nick and Neve, Paul (2013) Herbicide mixtures at high doses slow the evolution of resistance in experimentally evolving populations of Chlamydomonas reinhardtii. New Phytologist, Volume 198 (Number 3). pp. 938-945. doi:10.1111/nph.12195

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Official URL: http://dx.doi.org/10.1111/nph.12195

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Abstract

The widespread evolution of resistance to herbicides is a pressing issue in global agriculture. Evolutionary principles and practices are key to the management of this threat to global food security. The application of mixtures of herbicides has been advocated as an anti-resistance strategy, without substantial empirical support for its validation.
We evolved experimentally populations of the unicellular green chlorophyte, Chlamydomonas reinhardtii, to minimum inhibitory concentrations (MICs) of single-herbicide modes of action and to pair-wise and three-way mixtures between different herbicides at various total combined doses.
Herbicide mixtures were most effective when each component was applied at or close to its MIC. When doses were high, increasing the number of mixture components was also effective in reducing the evolution of resistance. Employing mixtures at low combined doses did not retard resistance evolution, even accelerating the evolution of resistance to some components. At low doses, increasing the number of herbicides in the mixture tended to select for more generalist resistance (cross-resistance).
Our results reinforce findings from the antibiotic resistance literature and confirm that herbicide mixtures can be very effective for resistance management, but that mixtures should only be employed where the economic and environmental context permits the applications of high combined doses.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Chlamydomonas reinhardtii, Herbicide resistance -- Research
Journal or Publication Title: New Phytologist
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0028-646X
Official Date: 2013
Dates:
DateEvent
2013Published
Volume: Volume 198
Number: Number 3
Page Range: pp. 938-945
DOI: 10.1111/nph.12195
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Leverhulme Trust (LT)

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