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Design, synthesis and structure–activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
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Fullam, Elizabeth, Talbot, James, Abuhammed, Areej, Westwood, Isaac, Davies, Stephen G., Russell, Angela J. and Sim, Edith (2013) Design, synthesis and structure–activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, Vol.23 (No.9). pp. 2759-2764. doi:10.1016/j.bmcl.2013.02.052 ISSN 0960-894X.
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2013.02.052
Abstract
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Bioorganic & Medicinal Chemistry Letters | ||||
Publisher: | Pergamon-Elsevier Science Ltd. | ||||
ISSN: | 0960-894X | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | Vol.23 | ||||
Number: | No.9 | ||||
Page Range: | pp. 2759-2764 | ||||
DOI: | 10.1016/j.bmcl.2013.02.052 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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