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Mutations in gyrA gene of Quinolone-resistant salmonella serotypes isolated from humans and animals
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Griggs, Deborah, Gensberg, Karl and Piddock, Laura J. V. (1996) Mutations in gyrA gene of Quinolone-resistant salmonella serotypes isolated from humans and animals. Antimicrobial Agents and Chemotherapy, Vol.40 (No.4). pp. 1009-1013. ISSN 0066-4804.
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Official URL: http://aac.asm.org/content/40/4/1009.abstract
Abstract
The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and
veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser833Phe) and Asp873Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala1193Glu. The data suggest that gyrA mutations are associated with
quinolone resistance in veterinary and clinical salmonella isolates and that the limits of the QRDR may require
revision.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Antimicrobial Agents and Chemotherapy | ||||
| Publisher: | American Society for Microbiology | ||||
| ISSN: | 0066-4804 | ||||
| Official Date: | April 1996 | ||||
| Dates: |
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| Volume: | Vol.40 | ||||
| Number: | No.4 | ||||
| Page Range: | pp. 1009-1013 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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