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Prevalence and subtypes of Ciprofloxacin-resistant Campylobacter spp. in commercial poultry flocks before, during, and after treatment with fluoroquinolones

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Humphrey, T. J., Jorgensen, F., Frost, J. A., Wadda, H., Domingue, G., Elviss, N. C., Griggs, Deborah and Piddock, Laura J. V. (2005) Prevalence and subtypes of Ciprofloxacin-resistant Campylobacter spp. in commercial poultry flocks before, during, and after treatment with fluoroquinolones. Antimicrobial Agents and Chemotherapy, Vol.49 (No.2). pp. 690-698. doi:10.1128/AAC.49.2.690-698.2005 ISSN 0066-4804.

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Official URL: http://dx.doi.org/10.1128/AAC.49.2.690-698.2005

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Abstract

Five commercial broiler chicken flocks were treated with either difloxacin or enrofloxacin for a clinically relevant infection, as instructed by a veterinarian. Campylobacters were isolated from individual fecal samples and from samples associated with the broiler environment before, during, and after treatment. Ciprofloxacin-resistant Campylobacter jejuni and/or C. coli strains were detected pretreatment in four flocks, but they constituted a very small proportion of the campylobacters present. When the broilers were treated with a fluoroquinolone, a rapid increase in the proportion of ciprofloxacin-resistant campylobacters was observed. During treatment nearly 100% of campylobacters were resistant, and in some flocks a high proportion of resistant strains persisted for up to 4 weeks after treatment. Prior to treatment a variety of campylobacter subtypes were present. During and after treatment considerable changes in both species and subtype prevalence were observed, but no single fluoroquinolone-resistant clone became dominant. Instead, resistant C. coli strains or a mixture of resistant C. coli and C. jejuni strains became dominant, whereas susceptible C. jejuni strains had usually been dominant prior to treatment. The resistant subtypes which emerged and became dominant were not always the same as those detected pretreatment. The persistence of resistant strains for up to 4 weeks posttreatment has important implications for any strategy designed to avoid the introduction of such strains into the food chain.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
ISSN: 0066-4804
Official Date: 2005
Dates:
DateEvent
2005Published
Volume: Vol.49
Number: No.2
Page Range: pp. 690-698
DOI: 10.1128/AAC.49.2.690-698.2005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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