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Quinolone resistance in veterinary isolates of salmonella

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Griggs, Deborah, Hall, M. C., Jin, Y. F. and Piddock, Laura J. V. (1994) Quinolone resistance in veterinary isolates of salmonella. Journal of Antimicrobial Chemotherapy, Vol.33 (No.6). pp. 1173-1189. doi:10.1093/jac/33.6.1173

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Official URL: http://dx.doi.org/10.1093/jac/33.6.1173

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Abstract

Twenty-seven nalidixic acid-resistant (MIC ^ 256 mg/L) isolates of salmonella from veterinary sources were also less susceptible to fluoroquinolones (range of MICs of
ciprofloxacin, 012-2 mg/L). Six isolates were cross-resistant to one or more chemically unrelated antibacterial agents. The concentrations of enrofloxacin that
inhibited DNA synthesis by 50% were similar to the MIC values for 23 of 27 isolates, suggesting a mutation in gyrA. Insertion of pNJR3-2 (gyrA) in nine of 20
isolates increased susceptibility to quinolones, suggesting that resistance was due to mutation in gyrA. Five of 27 isolates had reduced levels of accumulation of
enrofloxacin. Two of the five also had increased susceptibility to quinolones when pNJR3-2 was introduced. None of the outer membrane protein profiles of the resistant isolates differed from those of sensitive control strains. Three of 27 isolates had differences in lipopolysaccharide profiles compared to control strains. Although the MIC of ciprofloxacin was less than the recommended UK break point concentrations for most isolates, the increasing incidence of quinolone-resistance in salmonella from veterinary sources is a matter of concern.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press
ISSN: 0305-7453
Official Date: 1994
Dates:
DateEvent
1994Published
Volume: Vol.33
Number: No.6
Page Range: pp. 1173-1189
DOI: 10.1093/jac/33.6.1173
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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