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The killing action of fleroxacin upon Bacteroides fragilis
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Griggs, Deborah, Piddock, Laura J. V. and Wise, R. (1989) The killing action of fleroxacin upon Bacteroides fragilis. Journal of Antimicrobial Chemotherapy, Vol.23 (No.1). pp. 53-58. doi:10.1093/jac/23.1.53
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Official URL: http://dx.doi.org/10.1093/jac/23.1.53
Abstract
The killing kinetics of fleroxacin against four strains of Bacteroides fragilis were investigated. Viable counts were determined from 0 to 24 h after exposure to fleroxacin at multiples of the MIC. A one to three log reduction in viable count was observed after 2 h at 8 mg/l fleroxacin, and a more rapid rate of killing was seen at greater concentrations of the antimicrobial agent. An increase in cell length was observed at concentrations at and above the MIC from 2 h after exposure. The presence of a bacteriostatic concentration of chloramphenicol had negligible influence on viability but inhibited cell elongation.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Journal of Antimicrobial Chemotherapy | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 0305-7453 | ||||
| Official Date: | 1989 | ||||
| Dates: |
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| Volume: | Vol.23 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 53-58 | ||||
| DOI: | 10.1093/jac/23.1.53 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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