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The killing action of fleroxacin upon Bacteroides fragilis

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Griggs, Deborah, Piddock, Laura J. V. and Wise, R. (1989) The killing action of fleroxacin upon Bacteroides fragilis. Journal of Antimicrobial Chemotherapy, Vol.23 (No.1). pp. 53-58. doi:10.1093/jac/23.1.53

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Official URL: http://dx.doi.org/10.1093/jac/23.1.53

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Abstract

The killing kinetics of fleroxacin against four strains of Bacteroides fragilis were investigated. Viable counts were determined from 0 to 24 h after exposure to fleroxacin at multiples of the MIC. A one to three log reduction in viable count was observed after 2 h at 8 mg/l fleroxacin, and a more rapid rate of killing was seen at greater concentrations of the antimicrobial agent. An increase in cell length was observed at concentrations at and above the MIC from 2 h after exposure. The presence of a bacteriostatic concentration of chloramphenicol had negligible influence on viability but inhibited cell elongation.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press
ISSN: 0305-7453
Official Date: 1989
Dates:
DateEvent
1989Published
Volume: Vol.23
Number: No.1
Page Range: pp. 53-58
DOI: 10.1093/jac/23.1.53
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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