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The metabolism and pharmacokinetics of fleroxacin in healthy subjects
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Griggs, Deborah, Wise, R., Kirkpatrick, B. and Ashby, J. P. (1988) The metabolism and pharmacokinetics of fleroxacin in healthy subjects. The Journal of antimicrobial chemotherapy, Vol.22 (Suppl D). pp. 191-194. ISSN 0305-7453.
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Abstract
A 400 mg dose of fleroxacin was administered orally to six healthy male volunteers. Concentrations of fleroxacin and the N-demethyl and N-oxide metabolites were determined in serum and urine by HPLC. The serum metabolite levels were negligible. The N-oxide metabolite was measured in the serum of five subjects but did not exceed 4% of the corresponding fleroxacin level. N-demethyl fleroxacin was not detected (less than 0.1 mg/l). The urinary recovery of fleroxacin was 49.5% over 72 h; the N-demethyl and N-oxide metabolites accounted for 6.9% and 5.7%, respectively, of the administered dose.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | The Journal of antimicrobial chemotherapy | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 0305-7453 | ||||
| Official Date: | October 1988 | ||||
| Dates: |
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| Volume: | Vol.22 | ||||
| Number: | Suppl D | ||||
| Page Range: | pp. 191-194 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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