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Pharmacokinetics and tissue penetration of orally administered lomefloxacin
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Stone, J. W., Andrews, J. M., Ashby, J. P., Griggs, Deborah and Wise, R. (1988) Pharmacokinetics and tissue penetration of orally administered lomefloxacin. Antimicrobial Agents and Chemotherapy, Vol.32 (No.10). pp. 1508-1510. ISSN 0066-4804.
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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC175908...
Abstract
The pharmacokinetics of the quinolone lomefloxacin were determined following a single 400-mg oral dose given to each of six male volunteers. Concentrations in serum, urine, and cantharidin-induced inflammatory fluid were determined by a microbiological assay. Samples from two volunteers were also assayed by high-performance liquid chromatography. The mean peak level in serum, 4.7 micrograms/ml, was attained within 1 h of administration. The mean elimination half-life from serum was 7 h. Inflammatory fluid was penetrated rapidly, with a mean peak level of 3.5 micrograms/ml occurring after 2.7 h. The mean recovery of lomefloxacin from urine over 48 h was 76% of the administered dose. There was a minor peak on the high-performance liquid chromatography trace, suggesting a small amount of unidentified metabolite. This was present only in urine; no detectable metabolites were found in serum. This study suggests that either once-daily or twice-daily dosage of lomefloxacin should be sufficient to treat urinary or systemic infections, respectively, caused by susceptible pathogens.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Antimicrobial Agents and Chemotherapy | ||||
| Publisher: | American Society for Microbiology | ||||
| ISSN: | 0066-4804 | ||||
| Official Date: | 1988 | ||||
| Dates: |
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| Volume: | Vol.32 | ||||
| Number: | No.10 | ||||
| Page Range: | pp. 1508-1510 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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