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Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone
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Wise, R., Kirkpatrick, B., Ashby, J. and Griggs, Deborah (1987) Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone. Antimicrobial Agents and Chemotherapy, Vol.31 (No.2). pp. 161-163.
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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174683...
Abstract
A 400-mg dose of the trifluorinated quinolone Ro 23-6240 was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and cantharidin-induced inflammatory fluid were measured. Absorption was rapid, with a mean peak level in serum of 6.1 micrograms/ml, which was attained 0.71 h after administration. The elimination half-life in serum was 11.95 h. The agent penetrated the inflammatory fluid rapidly; the percent penetration was 89.7%. Urinary recovery of Ro 23-6240 was 58.6% by 72 h.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Antimicrobial Agents and Chemotherapy | ||||
| Publisher: | American Society for Microbiology | ||||
| ISSN: | 0066-4804 | ||||
| Official Date: | 1987 | ||||
| Dates: |
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| Volume: | Vol.31 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 161-163 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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