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A functional interaction between RIP140 and PGC-1 regulates the expression of the lipid droplet protein CIDEA
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Hallberg, M., Morganstein, D. L., Kiskinis, E., Shah, K., Kralli, A., Dilworth, S. M., White, R., Parker, M. G. and Christian, Mark (2008) A functional interaction between RIP140 and PGC-1 regulates the expression of the lipid droplet protein CIDEA. Molecular and Cellular Biology, 28 (22). pp. 6785-6795. doi:10.1128/MCB.00504-08 ISSN 0270-7306.
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Official URL: http://dx.doi.org/10.1128/MCB.00504-08
Abstract
Nuclear receptors activate or repress target genes depending on the recruitment of coactivators or corepressors. The corepressor RIP140 and the PPAR coactivator 1α (PGC-1α) both play key roles in the regulated transcription of genes involved in energy homeostasis. We investigated the roles of RIP140 and PGC-1α in controlling the expression of CIDEA, an important regulatory factor in adipose cell function and obesity. Ectopically expressed CIDEA surrounded lipid droplets in brown adipocytes and induced the formation of lipid droplets in nonadipogenic cell lines. The expression and promoter activity of CIDEA was repressed by RIP140 and induced by PGC-1α, mediated through the binding of estrogen-related receptor α and NRF-1 to their cognate binding sites. Importantly, we demonstrate that RIP140 interacts directly with PGC-1α and suppresses its activity. The direct antagonism of PGC-1α by RIP140 provides a mechanism for regulating target gene transcription via nuclear receptor-dependent and -independent pathways.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Molecular and Cellular Biology | ||||
Publisher: | American Society for Microbiology | ||||
ISSN: | 0270-7306 | ||||
Official Date: | September 2008 | ||||
Dates: |
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Volume: | 28 | ||||
Number: | 22 | ||||
Page Range: | pp. 6785-6795 | ||||
DOI: | 10.1128/MCB.00504-08 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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