Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

Tools
- Tools
+ Tools

Kagan, Valerian E., Konduru, Nagarjun V., Feng, Weihong, Allen, Brett L., Conroy, Jennifer, Volkov, Yuri, Vlasova, Irina I., Belikova, Natalia A., Yanamala, Naveena, Kapralov, Alexander et al.
(2010) Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nature Nanotechnology, 5 (5). pp. 354-359. doi:10.1038/nnano.2010.44

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1038/nnano.2010.44

Request Changes to record.

Abstract

We have shown previously that single-walled carbon nanotubes can be catalytically biodegraded over several weeks by the plant-derived enzyme, horseradish peroxidase1. However, whether peroxidase intermediates generated inside human cells or biofluids are involved in the biodegradation of carbon nanotubes has not been explored. Here, we show that hypochlorite and reactive radical intermediates of the human neutrophil enzyme myeloperoxidase catalyse the biodegradation of single-walled carbon nanotubes in vitro, in neutrophils and to a lesser degree in macrophages. Molecular modelling suggests that interactions of basic amino acids of the enzyme with the carboxyls on the carbon nanotubes position the nanotubes near the catalytic site. Importantly, the biodegraded nanotubes do not generate an inflammatory response when aspirated into the lungs of mice. Our findings suggest that the extent to which carbon nanotubes are biodegraded may be a major determinant of the scale and severity of the associated inflammatory responses in exposed individuals.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Journal or Publication Title: Nature Nanotechnology
Publisher: Nature Publishing Group
ISSN: 1748-3387
Official Date: 4 April 2010
Dates:
DateEvent
4 April 2010Published
Volume: 5
Number: 5
Page Range: pp. 354-359
DOI: 10.1038/nnano.2010.44
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us