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Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
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(2010) Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nature Nanotechnology, 5 (5). pp. 354-359. doi:10.1038/nnano.2010.44 ISSN 1748-3387.
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Official URL: http://dx.doi.org/10.1038/nnano.2010.44
Abstract
We have shown previously that single-walled carbon nanotubes can be catalytically biodegraded over several weeks by the plant-derived enzyme, horseradish peroxidase1. However, whether peroxidase intermediates generated inside human cells or biofluids are involved in the biodegradation of carbon nanotubes has not been explored. Here, we show that hypochlorite and reactive radical intermediates of the human neutrophil enzyme myeloperoxidase catalyse the biodegradation of single-walled carbon nanotubes in vitro, in neutrophils and to a lesser degree in macrophages. Molecular modelling suggests that interactions of basic amino acids of the enzyme with the carboxyls on the carbon nanotubes position the nanotubes near the catalytic site. Importantly, the biodegraded nanotubes do not generate an inflammatory response when aspirated into the lungs of mice. Our findings suggest that the extent to which carbon nanotubes are biodegraded may be a major determinant of the scale and severity of the associated inflammatory responses in exposed individuals.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine |
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| Journal or Publication Title: | Nature Nanotechnology | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 1748-3387 | ||||
| Official Date: | 4 April 2010 | ||||
| Dates: |
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| Volume: | 5 | ||||
| Number: | 5 | ||||
| Page Range: | pp. 354-359 | ||||
| DOI: | 10.1038/nnano.2010.44 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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