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Open-source genomic analysis of shiga-toxin–producing E. coli O104:H4
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(2011) Open-source genomic analysis of shiga-toxin–producing E. coli O104:H4. New England Journal Of Medicine , 365 (8). pp. 718-724. doi:10.1056/NEJMoa1107643 ISSN 0028-4793. An open access version can be found in:
Official URL: http://dx.doi.org/10.1056/NEJMoa1107643
Abstract
An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | New England Journal Of Medicine | ||||
Publisher: | Massachusetts Medical Society | ||||
ISSN: | 0028-4793 | ||||
Official Date: | 25 August 2011 | ||||
Dates: |
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Volume: | 365 | ||||
Number: | 8 | ||||
Page Range: | pp. 718-724 | ||||
DOI: | 10.1056/NEJMoa1107643 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Open Access Version: |
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