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Bistability in feedback circuits as a byproduct of evolution of evolvability
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Kuwahara, Hiroyuki and Soyer, Orkun S. (2012) Bistability in feedback circuits as a byproduct of evolution of evolvability. Molecular Systems Biology, Volume 8 (Number 564). Article no. 564. doi:10.1038/msb.2011.98 ISSN 1744-4292.
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Official URL: http://dx.doi.org/10.1038/msb.2011.98
Abstract
Noisy bistable dynamics in gene regulation can underlie stochastic switching and is demonstrated to be beneficial under fluctuating environments. It is not known, however, if fluctuating selection alone can result in bistable dynamics. Using a stochastic model of simple feedback networks, we apply fluctuating selection on gene expression and run in silico evolutionary simulations. We find that independent of the specific nature of the environment–fitness relationship, the main outcome of fluctuating selection is the evolution of increased evolvability in the network; system parameters evolve toward a nonlinear regime where phenotypic diversity is increased and small changes in genotype cause large changes in expression level. In the presence of noise, the evolution of increased nonlinearity results in the emergence and maintenance of bistability. Our results provide the first direct evidence that bistability and stochastic switching in a gene regulatory network can emerge as a mechanism to cope with fluctuating environments. They strongly suggest that such emergence occurs as a byproduct of evolution of evolvability and exploitation of noise by evolution.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Genetics, Molecular microbiology, Cell metabolism, Evolution (Biology), Cells -- Evolution | ||||
Journal or Publication Title: | Molecular Systems Biology | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1744-4292 | ||||
Official Date: | 17 January 2012 | ||||
Dates: |
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Volume: | Volume 8 | ||||
Number: | Number 564 | ||||
Page Range: | Article no. 564 | ||||
DOI: | 10.1038/msb.2011.98 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | University of Exeter, Carnegie-Mellon University. School of Computer Science |
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