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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
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(2013) Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, Volume 45 (Number 4). pp. 385-391. doi:10.1038/ng.2560 ISSN 1061-4036.
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Official URL: http://dx.doi.org/10.1038/ng.2560
Abstract
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ~30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Nature Genetics | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1061-4036 | ||||
Official Date: | April 2013 | ||||
Dates: |
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Volume: | Volume 45 | ||||
Number: | Number 4 | ||||
Page Range: | pp. 385-391 | ||||
DOI: | 10.1038/ng.2560 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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