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Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength
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Kerr, Michael I., Wall, Mark J. and Richardson, Magnus J. E. (2013) Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength. The Journal of Physiology, Volume 591 . pp. 3371-3380. doi:10.1113/jphysiol.2012.244392 ISSN 0022-3751.
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WRAP_Richardson_J Physiol-2013-Kerr-3371-80.pdf - Published Version Available under License Creative Commons Attribution. Download (758Kb) | Preview |
Official URL: http://dx.doi.org/10.1113/jphysiol.2012.244392
Abstract
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a mature state with decreased probability of release, smaller unitary amplitude and synaptic facilitation. Using paired recordings, we demonstrate that the developmental shift in release probability at synapses between rat somatosensory layer 5 thick-tufted pyramidal cells is due to a higher and more heterogeneous activation of presynaptic adenosine A1 receptors. Immature synapses under control conditions exhibited distributions of CV, failure rate and release probability that were almost coincident with the A1 receptor blocked condition; however, mature synapses under control conditions exhibited much broader distributions that spanned those of both the A1 receptor agonised and antagonised conditions. Immature and mature synapses expressed A1 receptors with no observable difference in functional efficacy and therefore the heterogeneous A1 receptor activation seen in the mature neocortex is due to increased adenosine concentrations that vary between synapses. Given the central role demonstrated for A1 receptor activation in determining synaptic amplitude and the statistics of transmission between mature layer 5 pyramidal cells, the emplacement of adenosine sources and sinks near the synaptic terminal could constitute a novel form of long-term synaptic plasticity.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Neurons, Synapses, Adenosine, Neural receptors, Neurotransmitter receptors, Neocortex | ||||
Journal or Publication Title: | The Journal of Physiology | ||||
Publisher: | Blackwell | ||||
ISSN: | 0022-3751 | ||||
Official Date: | 1 July 2013 | ||||
Dates: |
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Volume: | Volume 591 | ||||
Page Range: | pp. 3371-3380 | ||||
DOI: | 10.1113/jphysiol.2012.244392 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
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