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Bridging paradigms : hybrid mechanistic-discriminative predictive models
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Doyle, Orla M., Tsaneva-Atansaova, Krasimira, Harte, James M., Tiffin, Paul A., Tino, Peter and Díaz-Zuccarini, Vanessa (2013) Bridging paradigms : hybrid mechanistic-discriminative predictive models. IEEE Transactions on Biomedical Engineering, Volume 60 (Number 3). pp. 735-742. doi:10.1109/TBME.2013.2244598 ISSN 0018-9294.
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Official URL: http://dx.doi.org/10.1109/TBME.2013.2244598
Abstract
Many disease processes are extremely complex and characterized by multiple stochastic processes interacting simultaneously. Current analytical approaches have included mechanistic models and machine learning (ML), which are often treated as orthogonal viewpoints. However, to facilitate truly personalized medicine, new perspectives may be required. This paper reviews the use of both mechanistic models and ML in healthcare as well as emerging hybrid methods, which are an exciting and promising approach for biologically based, yet data-driven advanced intelligent systems.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | IEEE Transactions on Biomedical Engineering | ||||
Publisher: | Institute of Electrical and Electronics Engineers | ||||
ISSN: | 0018-9294 | ||||
Official Date: | March 2013 | ||||
Dates: |
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Volume: | Volume 60 | ||||
Number: | Number 3 | ||||
Page Range: | pp. 735-742 | ||||
DOI: | 10.1109/TBME.2013.2244598 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Innovative Medicines Initiative Joint Undertaking (IMI JU) , Engineering and Physical Sciences Research Council (EPSRC) , Biotechnology and Biological Sciences Research Council (BBSRC), NHS Midlands and East, WMG, Warwick Medical School, HEFCE Fellowship, Biological Sciences Research Council (BBSRC) , DISCIP-ULUS | ||||
Grant number: | 115008 (IMI JU); EP/I018638/1 (EPSRC); BB/J014699/1, BB/H012508/1 (BBSRC); FP7-288143 (DISCIP-ULUS) |
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