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Light drinking versus abstinence in pregnancy : behavioural and cognitive outcomes in 7-year-old children : a longitudinal cohort study
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Kelly, Yvonne, Iacovou, Maria, Quigley, Maria A., Gray, Ron, Wolke, Dieter, Kelly, John and Sacker, Amanda (2013) Light drinking versus abstinence in pregnancy : behavioural and cognitive outcomes in 7-year-old children : a longitudinal cohort study. BJOG : An International Journal of Obstetrics & Gynaecology, Volume 120 (Number 11). pp. 1340-1347. doi:10.1111/1471-0528.12246 ISSN 1470-0328.
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Official URL: http://dx.doi.org/10.1111/1471-0528.12246
Abstract
To assess whether light drinking in pregnancy is linked to unfavourable developmental outcomes in children.
Design
Prospective population-based cohort.
Setting
UK.
Population
Ten thousand five hundred and thirty-four 7-year-olds.
Methods
Quasi-experimental using propensity score matching (PSM) to compare children born to light (up to 2 units per week) and non-drinkers.
Main outcome measures
Behavioural difficulties rated by parents and teachers; cognitive test scores for reading, maths and spatial skills.
Results
Ordinary least squares (OLS) regression and PSM analyses are presented. For behavioural difficulties, unadjusted estimates for percentage standard deviation (SD) score differences ranged from 2 to 14%. On adjustment for potential confounders, differences were attenuated, with a loss of statistical significance, except for teacher-rated boys' difficulties. For boys, parent-rated behavioural difficulties: unadjusted, −11.5; OLS, −4.3; PSM, −6.8; teacher-rated behavioural difficulties: unadjusted, −13.9; OLS, −9.6; PSM, −10.8. For girls, parent-rated behavioural difficulties: unadjusted, −9.6; OLS, −2.9; PSM, −4.5; teacher-rated behavioural difficulties: unadjusted, −2.4; OLS, 4.9; PSM, 3.9. For cognitive test scores, unadjusted estimates for differences ranged between 12 and 21% of an SD score for reading, maths and spatial skills. After adjustment for potential confounders, estimates were reduced, but remained statistically significantly different for reading and for spatial skills in boys. For boys, reading: unadjusted, 20.9; OLS, 8.3; PSM, 7.3; maths: unadjusted, 14.7; OLS, 5.0; PSM, 6.5; spatial skills: unadjusted, 16.2; OLS, 7.6; PSM, 8.1. For girls, reading: unadjusted, 11.6; OLS, −0.3; PSM, −0.5; maths: unadjusted, 12.9; OLS, 4.3; PSM, 3.9; spatial skills: unadjusted, 16.2; OLS, 7.7; PSM, 6.4.
Conclusion
The findings suggest that light drinking during pregnancy is not linked to developmental problems in mid-childhood. These findings support current UK Department of Health guidelines on drinking during pregnancy.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Alcoholism in pregnancy | ||||
Journal or Publication Title: | BJOG : An International Journal of Obstetrics & Gynaecology | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 1470-0328 | ||||
Official Date: | October 2013 | ||||
Dates: |
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Volume: | Volume 120 | ||||
Number: | Number 11 | ||||
Page Range: | pp. 1340-1347 | ||||
DOI: | 10.1111/1471-0528.12246 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Economic and Social Research Council (Great Britain) (ESRC) | ||||
Grant number: | RES-596-28-0001 (ESRC) |
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