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Biomimetic three-dimensional microenvironment for controlling stem cell fate

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Zhang, H., Dai, S., Bi, J. and Liu, Kuo-Kang (2011) Biomimetic three-dimensional microenvironment for controlling stem cell fate. Interface Focus, Volume 1 (Number 5). pp. 792-803. doi:10.1098/rsfs.2011.0035

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Official URL: http://dx.doi.org/10.1098/​rsfs.2011.0035

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Abstract

Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This commitment is precisely controlled by the stem cell microenvironment. Engineering a biomimetic three-dimensional microenvironment enables a thorough understanding of the mechanisms of governing stem cell fate. We review the individual microenvironment components, including soluble factors, extracellular matrix, cell–cell interaction and mechanical stimulation. The perspectives in creating the biomimetic microenvironments are discussed with emerging techniques.

Item Type: Journal Article
Divisions: Faculty of Science > Engineering
Journal or Publication Title: Interface Focus
Publisher: The Royal Society Publishing
ISSN: 2042-8898
Official Date: 27 July 2011
Dates:
DateEvent
27 July 2011Published
Volume: Volume 1
Number: Number 5
Page Range: pp. 792-803
DOI: 10.1098/rsfs.2011.0035
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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