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Evaluation of glomerular filtration rate estimation by Cockcroft-Gault, Jelliffe, Wright and Modification of Diet in Renal Disease (MDRD) formulae in oncology patients
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Ainsworth, N. L., Marshall, A. (Andrea), Hatcher, H., Whitehead, L., Whitfield, G. A. and Earl, Helena M. (2012) Evaluation of glomerular filtration rate estimation by Cockcroft-Gault, Jelliffe, Wright and Modification of Diet in Renal Disease (MDRD) formulae in oncology patients. Annals of Oncology, Volume 23 (Number 7). pp. 1845-1853. doi:10.1093/annonc/mdr539 ISSN 0923-7534.
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Official URL: http://dx.doi.org/10.1093/annonc/mdr539
Abstract
Background: The aim was to evaluate the accuracy of Cockcroft–Gault, Jelliffe, Wright and Modification of Diet in
Renal Disease (MDRD) formulae as a substitute for the gold standard measure of glomerular filtration rate (GFR) using
chromium 51 EDTA.
Patients and methods: Retrospective analysis of GFR measurements in oncology patients from a University
Teaching Hospital over 3 years was carried out. Bias and precision of estimates of GFR were compared with measured
GFR.
Results: Six hundred and sixty patients with measured GFR (median 90 ml/min, range 23–179 ml/min) were identified.
Cockcroft–Gault produced the smallest bias (median percentage error −1.4%) and highest precision (median absolute
percentage error 14.0%) and was the most accurate for carboplatin dosing. For patients >30% over their ideal body
weight (IBW), using IBW + 30% in the Cockcroft–Gault formula was more precise than using actual body weight or
IBW. The Wright formula was most accurate for patients aged 70 + years and patients with a body mass index (BMI)
≥30 but overestimated GFR when GFR < 50 ml/min.
Conclusions: When measured GFR is unavailable, we advise estimating GFR using the Cockcroft–Gault formula and
using IBW + 30% for patients weighing >30% over their IBW. If the GFR is ≥50 ml/min and the patient is >70 years
and/or BMI ≥30, the Wright formula gives the best estimate of GFR.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Annals of Oncology | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0923-7534 | ||||
Official Date: | 21 November 2012 | ||||
Dates: |
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Volume: | Volume 23 | ||||
Number: | Number 7 | ||||
Page Range: | pp. 1845-1853 | ||||
DOI: | 10.1093/annonc/mdr539 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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