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Dietary cholecalciferol and calcium levels in a western-style defined rodent diet alter energy metabolism and inflammatory responses in mice

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Bastie, Claire C., Gaffney-Stomberg, E., Lee, T. -W. A., Dhima, E., Pessin, J. E. and Augenlicht, L. H. (2012) Dietary cholecalciferol and calcium levels in a western-style defined rodent diet alter energy metabolism and inflammatory responses in mice. Journal of Nutrition, Volume 142 (Number 5). pp. 859-865. doi:10.3945/jn.111.149914

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Official URL: http://dx.doi.org/10.3945/jn.111.149914

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Abstract

Male and female C57Bl6 mice were fed a control AIN76A diet, a new Western-style diet (NWD1) reflecting dietary patterns linked to elevated colon cancer incidence (higher fat, lower cholecalciferol, calcium, methyl donors, fiber), or NWD1 with elevated cholecalciferol and calcium (NWD2) from weaning. After 24 wk, serum 25-hydroxyvitamin D [25(OH)D] decreased by >80% in the NWD1 group compared with controls, but with no alteration in serum calcium or bone mineral density. The decreased serum 25(OH)D was prevented in the NWD2 group. After 32 wk, the NWD1 group compared with controls reduced overall energy expenditure by 15% without altering food consumption or physical activity and induced glucose intolerance, phenotypes associated with metabolic syndrome. These responses were unexpectedly exacerbated in the NWD2 group, further shifting mice toward greater fatty acid storage rather than oxidation compared with both control and NWD1 groups, but there was no change in physical activity, causing significant weight gain due to increased fat mass. The NWD1 group also exhibited inflammatory responses compared with controls, including macrophage-associated crown-like structures in epididymal adipose tissue and increased serum concentrations of the proinflammatory cytokine IL-1β, and of its targets, MCP-1 and Rantes, which were prevented or greatly mitigated in the NWD2 group. However, there was also elevated lipid storage in the liver and steatosis not seen in the control and NWD1 groups. Thus, elevating cholecalciferol and calcium in a Western-style diet can reduce inflammation associated with risk for colon tumor development, but interaction of nutrients in this diet can compromise liver function when fed long term.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Nutrition
Publisher: American Society for Nutrition
ISSN: 0022-3166
Official Date: 2012
Dates:
DateEvent
2012Published
Volume: Volume 142
Number: Number 5
Page Range: pp. 859-865
DOI: 10.3945/jn.111.149914
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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