Williams, Jonathan P., Brown, Jeffery M., Campuzano, Iain and Sadler, P. J.. (2010) Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS). Chemical Communications, Vol.46 (No.30). pp. 5458-5460. ISSN 1359-7345

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Abstract

Electron transfer dissociation (ETD) and collision induced dissociation (CID) have been used to locate the precise binding sites for platinum and ruthenium anticancer complexes on the peptide Substance P. We show that ETD combined with ion mobility-mass spectrometry significantly reduces mass spectral complexity and improves the S/N of the product-ions formed.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Charge transfer, Collisions (Nuclear physics), Dissociation, Peptides, Antineoplastic agents, Binding sites (Biochemistry)
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date:	14 August 2010
Volume:	Vol.46
Number:	No.30
Number of Pages:	3
Page Range:	pp. 5458-5460
Identification Number:	10.1039/c0cc00358a
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	University of Warwick Research Development Fund
URI:	http://wrap.warwick.ac.uk/id/eprint/5472

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