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Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS)
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Williams, Jonathan P., Brown, Jeffery M., Campuzano, Iain and Sadler, P. J. (2010) Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS). Chemical Communications, Vol.46 (No.30). pp. 5458-5460. doi:10.1039/c0cc00358a ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/c0cc00358a
Abstract
Electron transfer dissociation (ETD) and collision induced dissociation (CID) have been used to locate the precise binding sites for platinum and ruthenium anticancer complexes on the peptide Substance P. We show that ETD combined with ion mobility-mass spectrometry significantly reduces mass spectral complexity and improves the S/N of the product-ions formed.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Charge transfer, Collisions (Nuclear physics), Dissociation, Peptides, Antineoplastic agents, Binding sites (Biochemistry) | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 14 August 2010 | ||||
Dates: |
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Volume: | Vol.46 | ||||
Number: | No.30 | ||||
Number of Pages: | 3 | ||||
Page Range: | pp. 5458-5460 | ||||
DOI: | 10.1039/c0cc00358a | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | University of Warwick Research Development Fund |
Data sourced from Thomson Reuters' Web of Knowledge
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