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Application of tethered ruthenium catalysts to asymmetric hydrogenation of ketones, and the selective Hydrogenation of aldehydes
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Jolley, Katherine E., Zanotti-Gerosa, Antonio, Hancock, Fred, Dyke, Alan, Grainger, Damian M., Medlock, Jonathan A., Nedden, Hans Günter, Le Paih, Jacques J. M., Roseblade, Stephen J., Seger, Andreas, Sivakumar, Vilvanathan, Prokes, Ivan, Morris, David J. and Wills, Martin (2012) Application of tethered ruthenium catalysts to asymmetric hydrogenation of ketones, and the selective Hydrogenation of aldehydes. Advanced Synthesis & Catalysis, 354 (13). pp. 2545-2555. doi:10.1002/adsc.201200362 ISSN 1615-4150.
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Official URL: http://dx.doi.org/10.1002/adsc.201200362
Abstract
An improved method for the synthesis of tethered ruthenium(II) complexes of monosulfonylated diamines is described, together with their application to the hydrogenation of ketones and aldehydes. The complexes were applied directly, in their chloride form, to asymmetric ketone hydrogenation, to give products in excess of 99% ee in the best cases, using 30 bar of hydrogen at 60 °C, and to the selective reduction of aldehydes over other functional groups.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Hydrogenation, Ruthenium catalysts, Ketones | ||||
Journal or Publication Title: | Advanced Synthesis & Catalysis | ||||
Publisher: | Wiley-VCH Verlag GMBH | ||||
ISSN: | 1615-4150 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | 354 | ||||
Number: | 13 | ||||
Number of Pages: | 11 | ||||
Page Range: | pp. 2545-2555 | ||||
DOI: | 10.1002/adsc.201200362 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) |
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