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Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya

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Agoti, Charles N., Mwihuri, Alexander G., Sande, Charles J., Onyango, Clayton O., Medley, Graham, Cane, Patricia and Nokes, D. James (2012) Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya. Journal of Infectious Diseases, Volume 206 (Number 10). pp. 1532-1541. doi:10.1093/infdis/jis570 ISSN 0022-1899.

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Official URL: http://dx.doi.org/10.1093/infdis/jis570

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Abstract

Background: Respiratory syncytial virus (RSV) reinfects individuals repeatedly. The extent to which this is a consequence of RSV antigenic diversity is unclear.
Methods: Six-hundred thirty-five children from rural Kenya were closely monitored for RSV infection from birth through 3 consecutive RSV epidemics. RSV infections were identified by immunofluorescence testing of nasal washing samples collected during acute respiratory illnesses, typed into group A and B, and sequenced in the attachment (G) protein. A positive sample separated from a previous positive by ≥14 days was defined as a reinfection a priori.
Results: Phylogenetic analysis was undertaken for 325 (80%) of 409 identified infections, including 53 (64%) of 83 reinfections. Heterologous group reinfections were observed in 28 episodes, and homologous group reinfections were observed in 25 episodes; 10 involved homologous genotypes, 5 showed no amino acid changes, and 3 were separated by 21–24 days and were potentially persistent infections. The temporal distribution of genotypes among reinfections did not differ from that of single infections.
Conclusions: The vast majority of infection and reinfection pairs differed by group, genotype, or G amino acid sequence (ie, comprised distinct viruses). The extent to which this is a consequence of immune memory of infection history or prevalent diversity remains unclear.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Respiratory syncytial virus -- Kenya, Pediatrics -- Research -- Kenya , Pediatric respiratory diseases -- Kenya, Respiratory infections in children -- Kenya, Viral genetics -- Kenya, Microbial genetics, Immunogenetics -- Kenya, Communicable diseases in children -- Kenya
Journal or Publication Title: Journal of Infectious Diseases
Publisher: Oxford University Press
ISSN: 0022-1899
Official Date: November 2012
Dates:
DateEvent
November 2012Published
Volume: Volume 206
Number: Number 10
Page Range: pp. 1532-1541
DOI: 10.1093/infdis/jis570
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 24 December 2015
Date of first compliant Open Access: 24 December 2015
Funder: Wellcome Trust (London, England)
Grant number: 084663, 084538 (WT)

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