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FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways

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Salathia, Neeraj , Davis, Seth J., Lynn, James R. , Michaels, Scott D., Amasino, Richard M. and Millar, A. J. (Andrew J.). (2006) FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways. BMC Plant Biology, Vol.6 (No.10). ISSN 1471-2229

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Official URL: http://dx.doi.org/10.1186/1471-2229-6-10

Abstract

Background The circadian system drives pervasive biological rhythms in plants. Circadian clocks integrate endogenous timing information with environmental signals, in order to match rhythmic outputs to the local day/night cycle. Multiple signaling pathways affect the circadian system, in ways that are likely to be adaptively significant. Our previous studies of natural genetic variation in Arabidopsis thaliana accessions implicated FLOWERING LOCUS C (FLC) as a circadian-clock regulator. The MADS-box transcription factor FLC is best known as a regulator of flowering time. Its activity is regulated by many regulatory genes in the "autonomous" and vernalization-dependent flowering pathways. We tested whether these same pathways affect the circadian system. Results Genes in the autonomous flowering pathway, including FLC, were found to regulate circadian period in Arabidopsis. The mechanisms involved are similar, but not identical, to the control of flowering time. By mutant analyses, we demonstrate a graded effect of FLC expression upon circadian period. Related MADS-box genes had less effect on clock function. We also reveal an unexpected vernalization-dependent alteration of periodicity. Conclusion This study has aided in the understanding of FLC's role in the clock, as it reveals that the network affecting circadian timing is partially overlapping with the floral-regulatory network. We also show a link between vernalization and circadian period. This finding may be of ecological relevance for developmental programing in other plant species.

Item Type:	Journal Article
Subjects:	Q Science > QK Botany Q Science > QR Microbiology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Circadian rhythms, Plants, flowering of, Arabidopsis thaliana
Journal or Publication Title:	BMC Plant Biology
Publisher:	BioMed Central Ltd.
ISSN:	1471-2229
Date:	31 May 2006
Volume:	Vol.6
Number:	No.10
Identification Number:	10.1186/1471-2229-6-10
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Horticulture Research International (Great Britain), Life Sciences Research Foundation, Gatsby Charitable Foundation (GCF)
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URI:	http://wrap.warwick.ac.uk/id/eprint/552