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Evaluating genetic risk for prostate cancer among Japanese and Latinos
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(2012) Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiology Biomarkers & Prevention, Volume 21 (Number 11). pp. 2048-2058. doi:10.1158/1055-9965.EPI-12-0598 ISSN 1055-9965.
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Official URL: http://dx.doi.org/10.1158/1055-9965.EPI-12-0598
Abstract
Background
There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos.
Methods
Our first stage GWAS of prostate cancer included Japanese (cases/controls=1,033/1,042) and Latino (cases/controls=1,043/1,057) from the Multiethnic Cohort. Significant associations from stage 1 (P < 1.0×10−4) were examined in silico in GWAS of prostate cancer (stage 2) in Japanese (cases/controls=1,583/3,386) and Europeans (cases/controls=1,854/1,894).
Results
No novel stage 1 SNPs outside of known risk regions reached genome-wide significance. For Japanese, in stage 1, the most notable putative novel association was seen with 10 SNPs (P<8.0. x10−6) at chromosome 2q33; however, this was not replicated in stage 2. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage 1: OR=1.45; P=7.01×10−5 and stage 2: OR=1.58; P =3.05×10−7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele=1.10; P = 2.71×10−25 and OR=1.07; P = 1.02×10−16 for Japanese and Latinos, respectively).
Conclusion and Impact
Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings demonstrate that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Cancer Epidemiology Biomarkers & Prevention | ||||
Publisher: | American Association for Cancer Research | ||||
ISSN: | 1055-9965 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Volume 21 | ||||
Number: | Number 11 | ||||
Page Range: | pp. 2048-2058 | ||||
DOI: | 10.1158/1055-9965.EPI-12-0598 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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